(5E)-10-Oxo-19-norcholecalciferol

Base Information

• Chemical Name: (5E)-10-Oxo-19-norcholecalciferol
• CAS No.: 62743-71-9
• Molecular Formula: C₂₆H₄₂O₂
• Molecular Weight: 386.618
• Mol file: 62743-71-9.mol

Synonyms:

Chemical Property of (5E)-10-Oxo-19-norcholecalciferol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5E)-10-Oxo-19-norcholecalciferol

There total 10 articles about (5E)-10-Oxo-19-norcholecalciferol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(5E)-10-Oxo-19-norcholecalciferolacetat (155589-97-2) → (5E)-10-Oxo-19-norcholecalciferol (62743-71-9,62743-72-0,95480-84-5,121144-32-9)

Guidance literature:

With sodium methylate; In methanol; diethyl ether;

Reference yield: 41.0%

5,6-trans-vitamin D3 (67-97-0,7489-19-2,57651-82-8,57651-83-9,98744-46-8,98818-17-8,22350-41-0) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + (5E)-10-Oxo-19-norcholecalciferol (62743-71-9,62743-72-0,95480-84-5,121144-32-9) + 8α-Hydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one (118746-80-8,131335-90-5)

Guidance literature:

With bis(tetra-n-butylammonium) tetrakis(benzenethiolato-μ3-sulfidoiron); oxygen; In acetonitrile; for 1h; Product distribution; Mechanism; Ambient temperature;

DOI:10.1016/S0040-4039(00)97764-5

Reference yield: 15.0%

vitamin D3 (67-97-0) → 5,6-trans-vitamin D3 (67-97-0,7489-19-2,57651-82-8,57651-83-9,98744-46-8,98818-17-8,22350-41-0) + (5E)-10-Oxo-19-norcholecalciferol (62743-71-9,62743-72-0,95480-84-5,121144-32-9)

Guidance literature:

With bis(tetra-n-butylammonium) tetrakis(benzenethiolato-μ3-sulfidoiron); oxygen; In acetonitrile; at 50 ℃; for 3h;

DOI:10.1016/S0040-4039(00)97764-5

upstream raw materials:

vitamin D₃

5,6-trans-vitamin D₃

(5E)-10-Oxo-19-norcholecalciferolacetat

4-hydroxycyclohexanone

Downstream raw materials:

5,6-trans-vitamin D₃

Refernces

• 1、 Yamamoto,Imae,Yamada. "Biomimetic oxidation of vitamin D by iron-sulfur model cluster and dioxygen system". . p. 4903 - 4906. Retrieved 2007/10/02.