benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine

Base Information

• Chemical Name: benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine
• CAS No.: 75898-61-2
• Molecular Formula: C₂₅H₂₉N₃O₈
• Molecular Weight: 499.521
• Mol file: 75898-61-2.mol

Synonyms:

Chemical Property of benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine

There total 2 articles about benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-(L)-Glu-OBn (3705-42-8) → benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine (75898-61-2)

Guidance literature:

With 1,4-dioxane; tributyl-amine; chloroformic acid ethyl ester; anschliessend Behandeln mit L-Glutamin und K₂CO₃ in wss. Dioxan;

DOI:10.1021/ja01642a081

Reference yield:

L-glutamine (56-85-9,26700-71-0) + γ-OSu-N-Z-L-Glu-OBzl (34897-67-1) → benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine (75898-61-2)

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide; for 24h; Yield given; Ambient temperature;

Reference yield: 84.0%

benzyloxycarbonyl-α-benzyl-γ-L-glutamyl-L-glutamine (75898-61-2) → L-γ-glutamyl-L-glutamine (10148-81-9)

Guidance literature:

With hydrogen; palladium; In methanol; acetic acid; for 5h;

upstream raw materials:

Cbz-(L)-Glu-OBn

L-glutamine

γ-OSu-N-Z-L-Glu-OBzl

Downstream raw materials:

L-γ-glutamyl-L-glutamine

Refernces

• 1、 Noda, Kosaku,Igata, Keiko,Horikawa, Yoshiko,Fujii, Hisao. "Synthesis of γ-Glutamyl Peptides Catalyzed by Transamidase from Bacillus natto". . p. 2419 - 2424. Retrieved 2007/10/02.