Technology Process of (S)-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-(4-nitrophenyl)propan-1-ol
There total 8 articles about (S)-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-(4-nitrophenyl)propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-Benzyl-1,4-dihydronicotinamide;
In
methanol;
for 4h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 12 h / Heating
2: 55 percent / Et3N / CH2Cl2 / 1) -20 deg C, 1 h, 2) room temperature, 24 h
3: acetonitrile / 8 h / Heating
4: 72 percent / BNAH / methanol / 4 h / Ambient temperature
With
thionyl chloride; 1-Benzyl-1,4-dihydronicotinamide; triethylamine;
In
methanol; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 82 percent / fuming nitric acid / aq. H2SO4 / 0.25 h / Ambient temperature
2: 80 percent / HCl gas / 3 h / Heating
3: 69 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
4: 55 percent / Et3N / CH2Cl2 / 1) -20 deg C, 1 h, 2) room temperature, 24 h
5: acetonitrile / 8 h / Heating
6: 72 percent / BNAH / methanol / 4 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; 1-Benzyl-1,4-dihydronicotinamide; nitric acid; triethylamine;
In
methanol; diethyl ether; dichloromethane; sulfuric acid; acetonitrile;