6'-acetylkanamycin

Base Information

• Chemical Name: 6'-acetylkanamycin
• CAS No.: 31657-07-5
• Molecular Formula: C₂₀H₃₈N₄O₁₂
• Molecular Weight: 526.541
• Mol file: 31657-07-5.mol

Synonyms:

Chemical Property of 6'-acetylkanamycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6'-acetylkanamycin

There total 4 articles about 6'-acetylkanamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Kanamycin A sulfate (3847-27-6,25389-94-0,64013-70-3,81129-79-5,84278-20-6,94108-19-7,94237-36-2,133-92-6) → 6'-acetylkanamycin (31657-07-5)

Guidance literature:

With aminoglycoside 6'-acetyltransferase (AAC(6')); In phosphate buffer; at 37 ℃; pH=7.0;

DOI:10.7164/antibiotics.53.1168

Reference yield:

kanamycin A (59-01-8) → 6'-acetylkanamycin (31657-07-5) + C18H35N4O14P(2-) + C20H37N4O15P(2-)

Guidance literature:

Product distribution; Rate constant; reaction with aminoglycoside resistance enzyme from family of aminoglycoside 3'-phosphotransferases ;

DOI:10.1021/ja964278w

Reference yield:

kanamycin A (59-01-8) + acetylcoenzyme A (72-89-9) → 6'-acetylkanamycin (31657-07-5)

Guidance literature:

With C-terminal histidine-tagged aminoglycoside acetyltransferase(6')-APH(2")(pET22b); for 0.5h; pH=6.6; Reagent/catalyst; regioselective reaction; Kinetics; Enzymatic reaction;

DOI:10.1002/cbic.200900584

upstream raw materials:

kanamycin A

Kanamycin A sulfate

acetylcoenzyme A

Refernces

• 1、 Hotta,Sunada,Ikeda,Kondo. "Double stage activity in aminoglycoside antibiotics". . p. 1168 - 1174. Retrieved 2007/10/03.
• 2、 Umezawa,Okanishi,Utahara,Maeda,Kondo. "Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.". . p. 136 - 141. Retrieved 2007/10/10.