RUBUSOSIDE

Base Information

• Chemical Name: RUBUSOSIDE
• CAS No.: 64849-39-4
• Molecular Formula: C₃₂H₅₀O₁₃
• Molecular Weight: 642.741
• Hs Code.: 29389090
• Mol file: 64849-39-4.mol

Synonyms:1H-2,10a-Ethanophenanthrene,kaur-16-en-18-oic acid deriv.; Rubusoside

Chemical Property of RUBUSOSIDE

Chemical Property:

• Vapor Pressure: 8.59E-30mmHg at 25°C
• Melting Point: 178～181℃
• Boiling Point: 802.5oC at 760 mmHg
• PKA: 12.51±0.70(Predicted)
• Flash Point: 251.9oC
• PSA: 215.83000
• Density: 1.45g/cm3
• LogP: -0.76230
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Rubusoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Rubusoside is used as a nutritive sweetener, derived from .Stevia rebaudiana Stevia glycosiede.

Technology Process of RUBUSOSIDE

There total 6 articles about RUBUSOSIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.6%

β-D-glucose (492-61-5) + ent-13-hydroxykaur-16-en-19-oic acid (471-80-7,29584-19-8) → steviol 19β-glucopyranosyl ester (64977-89-5,1185737-16-9) + steviol 19-β-gentiobiosyl ester (140447-36-5) + steviol 13-O-β-glucopyranoside 19-β-glucopyranosyl ester (64849-39-4,104873-42-9)

Guidance literature:

In ethanol; at 25 ℃; for 72h; culture of Eucalyptus perriniana;

DOI:10.1016/0031-9422(91)83450-Y

Reference yield:

UDP-glucose (133-89-1) + steviol (29584-19-8,471-80-7) → 13-hydroxy-ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester (1185737-16-9) + 13-O-β-glucopyranosol steviol (60129-60-4,64977-87-3) + 13-O-β-D-glucopyranosyl-19-O-β-D-glucopyranosylsteviol (64849-39-4,104873-42-9)

Guidance literature:

With glucosyltransferase from Andrographis paniculata; In aq. buffer; at 30 ℃; for 12h; pH=7.4; Enzymatic reaction;

DOI:10.1021/acs.orglett.8b02146

Reference yield:

stevioside (57817-89-7) → 13-hydroxy-ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester (1185737-16-9) + β-D-glucose (492-61-5) + steviol (29584-19-8,471-80-7) + 13-O-β-D-glucopyranosyl-19-O-β-D-glucopyranosylsteviol (64849-39-4,104873-42-9)

Guidance literature:

With β-galactosidase from Sulfolobus solfataricus; water; at 85 ℃; for 3h; Reagent/catalyst; chemospecific reaction; Enzymatic reaction;

DOI:10.1016/j.molcatb.2014.03.011

upstream raw materials:

stevioside

UDP-glucose

13-O-β-glucopyranosol steviol

steviol

Downstream raw materials:

stevioside

13-O-β-glucopyranosyl-steviol

rebaudioside D

rebaudioside A

Refernces

• 1、 Li, Yuan,Lin, Hui-Xin,Wang, Jian,Yang, Jian,Lai, Chang-Jiang-Sheng,Wang, Xing,Ma, Bao-Wei,Tang, Jin-Fu,Li, Yong,Li, Xin-Lin,Guo, Juan,Gao, Wei,Huang, Lu-Qi. "Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis". supporting information. p. 5999 - 6002. Retrieved 2018/10/20.
• 2、 Orihara, Yutaka,Saiki, Kenji,Furuya, Tsutomu. "BIOTRANSFORMATION OF STEVIOL BY CULTURED CELLS OF EUCALYPTUS PERRINIANA AND COFFEE ARABICA". . p. 3989 - 3992. Retrieved 2007/10/02.