(R)-Chroman-2-ylmethanaine

Base Information

• Chemical Name: (R)-Chroman-2-ylmethanaine
• CAS No.: 404337-71-9
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Hs Code.: 2932999099
• Mol file: 404337-71-9.mol

Synonyms:(R)-Chroman-2-ylmethanaine

Chemical Property of (R)-Chroman-2-ylmethanaine

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 278.951 °C at 760 mmHg
• PKA: 9.14±0.29(Predicted)
• Flash Point: 129.241 °C
• PSA: 35.25000
• Density: 1.073 g/cm³
• LogP: 2.03920

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-Chroman-2-ylmethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Chroman-2-ylmethanaine

There total 25 articles about (R)-Chroman-2-ylmethanaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(R)-chroman-2-carboxylic acid amide (437763-61-6) → (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanamine (404337-71-9)

Guidance literature:

With diborane; In tetrahydrofuran; Inert atmosphere; Reflux;

DOI:10.1021/jm2007886

Reference yield: 62.0%

(R)-chroman-2-carbonitrile (850848-21-4) → (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanamine (404337-71-9)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol; at 60 ℃; for 10h; under 2250.23 Torr;

Reference yield:

ethyl Chroman-2-carboxylate (24698-77-9) → (-)-(R)-3,4-dihydro-2H-1-benzopyran-2-methanamine (404337-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: lipase from Pseudomonas fluorescens; sodium hydroxide / tetrahydrofuran; water / 20 °C / pH 8 / aq. phosphate buffer; Enzymatic reaction

2: ammonia; ammonium chloride / water / 2 h / 100 °C

3: diborane / tetrahydrofuran / Inert atmosphere; Reflux

With lipase from Pseudomonas fluorescens; ammonia; ammonium chloride; sodium hydroxide; diborane; In tetrahydrofuran; water;

DOI:10.1021/jm2007886

upstream raw materials:

(R)-chroman-2-carboxylic acid amide

(R)-2-(azidomethyl)chroman

(E)-2-propenylphenol

o-Allylphenol

Downstream raw materials:

(2R)-3,4-dihydro-2H-chromen-2-ylmethylamine hydrochloride

(R)-tert-butyl (8-(2,6-dichlorophenyl)-2-chromanyl)methylcarbamate

Refernces

• 1、 -. "CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF". Page/Page column 59; 64-66. . Retrieved 2010/11/28.
• 2、 -. "CHROMANONE DERIVATIVES". . . Retrieved 2008/06/13.