Technology Process of CID 10702553
There total 2 articles about CID 10702553 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-Difluoro-4-nitrophenol;
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
for 1.5h;
under 760.051 Torr;
With
hydrogenchloride;
In
ethanol; water;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydroxide / tert-butyl alcohol / 16 h / 80 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / methanol; water / 17 h / 20 - 45 °C / 775.74 Torr / Inert atmosphere
2.2: 0.25 h / 0 - 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; potassium hydroxide;
In
methanol; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / dimethyl sulfoxide / 16 h / 50 °C / Inert atmosphere
2: palladium 10% on activated carbon; triethylamine / tetrahydrofuran; water / 36 h / 45 °C / 775.74 Torr / Inert atmosphere
3: pyridine / tetrahydrofuran / 1 h / 0 °C
4: N,N-dimethyl-formamide / 2 h / 60 °C
5: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
With
pyridine; palladium 10% on activated carbon; potassium carbonate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;