(2R)-N2-(2-chloroethyl)-N2-(3-chloropyrazin-2-yl)propane-1,2-diamine

Base Information

• Chemical Name: (2R)-N2-(2-chloroethyl)-N2-(3-chloropyrazin-2-yl)propane-1,2-diamine
• CAS No.: 639029-52-0
• Molecular Formula: C9H13 Cl N4 . Cl H
• Molecular Weight: 249.143
• Mol file: 639029-52-0.mol

Synonyms:Pyrazine,2-chloro-3-[(2R)-2-methyl-1-piperazinyl]-, monohydrochloride (9CI);(2R)-1-(3-Chloro-2-pyrazinyl)-2-methylpiperazine hydrochloride

Chemical Property of (2R)-N2-(2-chloroethyl)-N2-(3-chloropyrazin-2-yl)propane-1,2-diamine

Chemical Property:

• Vapor Pressure: 3.92E-05mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-N2-(2-chloroethyl)-N2-(3-chloropyrazin-2-yl)propane-1,2-diamine

There total 6 articles about (2R)-N2-(2-chloroethyl)-N2-(3-chloropyrazin-2-yl)propane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine (313657-76-0) → (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride (639029-52-0)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 72 ℃; for 0.166667h;

Reference yield:

(2R)-methylpiperazine (75336-86-6) → (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride (639029-52-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane; acetonitrile / 1.5 h / 20 - 30 °C

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 41.5 h / 127 - 133 °C

3: sulfuric acid / water; isopropyl alcohol / 0.5 h / 77 - 83 °C

4: hydrogenchloride / water; ethyl acetate / 0.17 h / 72 °C

With hydrogenchloride; sulfuric acid; potassium carbonate; triethylamine; In DMF (N,N-dimethyl-formamide); dichloromethane; water; ethyl acetate; isopropyl alcohol; acetonitrile;

Reference yield:

(R)-2-methylpiperazine, L-tartrate (126458-16-0,126458-15-9) → (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride (639029-52-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / branched octane; water / 2 h / 80 °C

2: triethylamine / dichloromethane; acetonitrile / 1.5 h / 20 - 30 °C

3: potassium carbonate / DMF (N,N-dimethyl-formamide) / 41.5 h / 127 - 133 °C

4: sulfuric acid / water; isopropyl alcohol / 0.5 h / 77 - 83 °C

5: hydrogenchloride / water; ethyl acetate / 0.17 h / 72 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; potassium carbonate; triethylamine; In DMF (N,N-dimethyl-formamide); branched octane; dichloromethane; water; ethyl acetate; isopropyl alcohol; acetonitrile;

upstream raw materials:

(R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine

(R)-2-methylpiperazine, L-tartrate

(2R)-methylpiperazine

(RS)-2-methylpiperazine

Refernces