TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE

Base Information

• Chemical Name: TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE
• CAS No.: 40500-05-8
• Molecular Formula: C7H11ClO2
• Molecular Weight: 162.616
• Hs Code.: 2932999099
• Mol file: 40500-05-8.mol

Synonyms:(Tetrahydro-2H-pyran-4-yl)acetylchloride;Tetrahydropyran-4-acetyl chloride;Tetrahydropyran-4-acetyl chloride ,95%;Tetrahydro-2h-pyran-4-ylacetyl chloride;

Chemical Property of TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.0944mmHg at 25°C
• Refractive Index: 1.453
• Boiling Point: 223.8 °C at 760 mmHg
• Flash Point: 83 °C
• PSA: 26.30000
• Density: 1.132 g/cm³
• LogP: 1.56850

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Tetrahydro-2H-pyran-4-yl)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE

There total 3 articles about TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(tetrahydro-2H-pyran-4-yl)acetic acid (85064-61-5) → 2-(tetrahydro-2H-pyran-4-yl)acetyl chloride (40500-05-8)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

2-(tetrahydro-2H-pyran-4-yl)acetic acid (85064-61-5) + oxalyl dichloride (79-37-8) → 2-(tetrahydro-2H-pyran-4-yl)acetyl chloride (40500-05-8)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

→ 2-(tetrahydro-2H-pyran-4-yl)acetyl chloride (40500-05-8)

Guidance literature:

upstream raw materials:

2-(tetrahydro-2H-pyran-4-yl)acetic acid

oxalyl dichloride

Downstream raw materials:

C₃₀H₃₄ClN₃O₆

Refernces

• 1、 -. "7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD)". Paragraph 00141-00142; 00190; 00193. . Retrieved 2021/10/11.
• 2、 Chen, Hui,Guo, Liangliang,Yu, Shouyun. "Primary, Secondary, and Tertiary γ-C(sp3)-H Vinylation of Amides via Organic Photoredox-Catalyzed Hydrogen Atom Transfer". supporting information. p. 6255 - 6259. Retrieved 2018/10/05.