Welcome to LookChem.com Sign In|Join Free
  • or

Encyclopedia

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Base Information Edit
  • Chemical Name:N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
  • CAS No.:162012-67-1
  • Molecular Formula:C14H7ClF4N4O2
  • Molecular Weight:336.685
  • Hs Code.:2933990090
  • European Community (EC) Number:808-276-1
  • DSSTox Substance ID:DTXSID60442902
  • Wikidata:Q72451198
  • Mol file:162012-67-1.mol
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Synonyms:162012-67-1;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline;4-QUINAZOLINAMINE, N-(3-CHLORO-4-FLUOROPHENYL)-7-FLUORO-6-NITRO-;MFCD09998825;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine;4-[(3-chloro-4-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline;(3-Chloro-4-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine;C14H7ClF2N4O2;SCHEMBL25241;AMY6970;DTXSID60442902;BCP08568;CS-M0991;N-(3-chloro-4-fluoro-phenyl)-7-fluoro-6-nitro-quinazolin-4-amine;AKOS015917847;AKOS034830279;PB34506;AC-27054;AS-11445;SY028080;A3594;C3276;FT-0687659;A810325;4-(3-chloro-4-fluorophenyl)amino-6-nitro-7-fluoroquinazoline;6-nitro-4-(3-chloro-4-fluorophenylamino)-7-fluoro-quinazoline;4-[(3-chloro-4-fluoro-phenyl)amino]-7-fluoro-6-nitro-quinazoline;4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoro-quinazoline;4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoroquinazoline;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazoline-4-amine;(3-Chloro-4-fluoro-phenyl)-(7-fluoro-6-nitro-quinazoline-4-yl)-amine;(3-CHLORO-4-FLUOROPHENYL)(7-FLUORO-6-NITROQUINAZOLIN-4-YL)AMINE;4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-7-FLUORO-6-NITROQUNINAZOLINE

Suppliers and Price of N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
  • 100mg
  • $ 95.00
  • TRC
  • 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
  • 10g
  • $ 970.00
  • TCI Chemical
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
  • 25G
  • $ 436.00
  • TCI Chemical
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
  • 5G
  • $ 146.00
  • SynQuest Laboratories
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 97%
  • 25 g
  • $ 180.00
  • SynQuest Laboratories
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 97%
  • 5 g
  • $ 50.00
  • SynQuest Laboratories
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 97%
  • 1 g
  • $ 35.00
  • Matrix Scientific
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 95+%
  • 1g
  • $ 1428.00
  • Matrix Scientific
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 95+%
  • 250mg
  • $ 643.00
  • Crysdot
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 98%
  • 25g
  • $ 81.00
Total 161 raw suppliers
Chemical Property of N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine Edit
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:242-244℃ 
  • Refractive Index:1.707 
  • Boiling Point:488.589 °C at 760 mmHg 
  • PKA:5.07±0.70(Predicted) 
  • Flash Point:249.29 °C 
  • PSA:83.63000 
  • Density:1.617 g/cm3 
  • LogP:4.80940 
  • Storage Temp.:2-8°C(protect from light) 
  • Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated) 
  • XLogP3:4.1
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:7
  • Rotatable Bond Count:2
  • Exact Mass:336.0225595
  • Heavy Atom Count:23
  • Complexity:442
Purity/Quality:

99% *data from raw suppliers

4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC(=C(C=C1NC2=NC=NC3=CC(=C(C=C32)[N+](=O)[O-])F)Cl)F
  • Uses 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
Technology Process of N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

There total 18 articles about N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
In isopropyl alcohol; for 4h; Product distribution / selectivity; Reflux;
Guidance literature:
With copper(l) iodide; potassium carbonate; 4-hydroxyproline; In N,N-dimethyl-formamide; at 80 ℃; for 0.166667h; Reagent/catalyst; Temperature; Time; Microwave irradiation;
Post RFQ for Price