1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE

Base Information

• Chemical Name: 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE
• CAS No.: 669008-25-7
• Molecular Formula: C8H17NO2S
• Molecular Weight: 191.294
• Hs Code.: 2935009090
• Mol file: 669008-25-7.mol

Synonyms:cyclopropanesulfonamide, N-(1,1-dimethylethyl)-1-methyl-;N-tert-Butyl-1-methylcyclopropanesulfonamide

Chemical Property of 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.492
• Boiling Point: 259.008 °C at 760 mmHg
• PKA: 12.01±0.20(Predicted)
• Flash Point: 110.445 °C
• PSA: 54.55000
• Density: 1.12 g/cm³
• LogP: 2.72850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

N-(tert-Butyl)-1-methylcyclopropane-1-sulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE

There total 5 articles about 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butyl-(3-chloro)propylsulfonamide (63132-85-4) + methyl iodide (74-88-4) → N-(tert-butyl)-1-methylcyclopropane-1-sulfonamide (669008-25-7)

Guidance literature:

N-tert-butyl-(3-chloro)propylsulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -69 - 20 ℃; for 4.33333h;

methyl iodide; In tetrahydrofuran; hexane; at -65 - 50 ℃; for 4.66667h;

Reference yield: 97.0%

→ N-(tert-butyl)-1-methylcyclopropane-1-sulfonamide (669008-25-7)

Guidance literature:

Reference yield: 97.0%

→ N-(tert-butyl)-1-methylcyclopropane-1-sulfonamide (669008-25-7) + N-tert-butyl-(1-allyl)cyclopropyl-sulfonamide (669008-27-9)

Guidance literature:

upstream raw materials:

N-tert-butyl-(3-chloro)propylsulfonamide

methyl iodide

N-t-butyl-1-cyclopropylsulfonamide

Downstream raw materials:

1-methylcyclopropane-1-sulfonamide

Refernces

• 1、 -. "(1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV". Paragraph 0104-0105. . Retrieved 2014/10/29.
• 2、 -. "HCV NS3 PROTEASE INHIBITORS". Page/Page column 35-36. . Retrieved 2012/04/10.