8-Quinolinemethanol

Base Information

• Chemical Name: 8-Quinolinemethanol
• CAS No.: 16032-35-2
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• Mol file: 16032-35-2.mol

Synonyms:8-Quinolinylmethanol;

Chemical Property of 8-Quinolinemethanol

Chemical Property:

• Melting Point: 75-76℃
• Boiling Point: 334.8 °C at 760 mmHg
• PKA: 13.80±0.10(Predicted)
• Flash Point: 156.3 °C
• PSA: 33.12000
• Density: 1.218 g/cm³
• LogP: 1.72710

Purity/Quality:

98%min ^*data from raw suppliers

Quinolin-8-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Quinolinemethanol

There total 21 articles about 8-Quinolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(quinolin-8-yl)methyl acetate (79663-29-9) → 8-hydroxymethylquinoline (16032-35-2)

Guidance literature:

With sodium hydroxide; In methanol; for 1.5h; Heating;

DOI:10.1248/cpb.37.2109

Reference yield: 81.0%

quinoline-8-carboxylic acid ethylester (25635-22-7) → 8-hydroxymethylquinoline (16032-35-2)

Guidance literature:

Reference yield: 75.0%

8-formylquinoline (38707-70-9) → 8-hydroxymethylquinoline (16032-35-2)

Guidance literature:

8-formylquinoline; With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h;

With water; ammonium chloride; In methanol;

upstream raw materials:

8-formylquinoline

8-(aminomethyl)quinoline

8-bromomethyl-quinoline

quinoline-8-carboxylic acid ethylester

Downstream raw materials:

1-Benzyl-8-(5-methyl-1H-benzoimidazole-2-sulfinylmethyl)-1,2,3,4-tetrahydro-quinoline

1-Benzyl-8-(5-methyl-1H-benzoimidazol-2-ylsulfanylmethyl)-1,2,3,4-tetrahydro-quinoline

8-(1H-Benzoimidazole-2-sulfinylmethyl)-1-ethyl-1,2,3,4-tetrahydro-quinoline

(1-Benzyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol

Refernces

• 1、 Wang, Feifan,Huang, Fei,Yu, Yingliang,Zhou, Shuangliu,Wang, Zhenghua,Zhang, Wu. "Monodisperse CuPd alloy nanoparticles supported on reduced graphene oxide as efficient catalyst for directed C?H activation". . . Retrieved 2021/03/01.
• 2、 Li, Yushu,Wong, Luet L.. "Multi-Functional Oxidase Activity of CYP102A1 (P450BM3) in the Oxidation of Quinolines and Tetrahydroquinolines". supporting information. p. 9551 - 9555. Retrieved 2019/08/06.