H-ALA-PRO-OME HCL

Base Information

• Chemical Name: H-ALA-PRO-OME HCL
• CAS No.: 71067-42-0
• Molecular Formula: C₉H₁₇N₂O₃*Cl
• Molecular Weight: 236.699
• Mol file: 71067-42-0.mol

Synonyms:H-ALA-PRO-OME HCL

Chemical Property of H-ALA-PRO-OME HCL

Chemical Property:

• PSA: 72.63000
• LogP: 0.93780
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

H-Ala-Pro-OMe.HCl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ALA-PRO-OME HCL

There total 3 articles about H-ALA-PRO-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-methyl 1-((S)-2-((tert-butoxycarbonyl)amino)propanoyl)pyrrolidine-2-carboxylate (33300-71-9) → alanylproline methyl ester hydrochloride (71067-42-0)

Guidance literature:

With hydrogenchloride; In acetic acid; for 1h;

Reference yield:

methyl (2S)-pyrrolidine carboxylate (2577-48-2) → alanylproline methyl ester hydrochloride (71067-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dicyclohexylcarbodiimide / CH₂Cl₂

2: HCl / CH₂Cl₂ / 0 °C

With hydrogenchloride; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/ja00283a031

Reference yield:

L-proline methyl ester monohydrochloride (2133-40-6) → alanylproline methyl ester hydrochloride (71067-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / N-methylpiperidine / dioxane / 17 h

2: 96 percent / 1M HCl / acetic acid / 1 h

With N-methylcyclohexylamine; hydrogenchloride; In 1,4-dioxane; acetic acid;

upstream raw materials:

(S)-methyl 1-((S)-2-((tert-butoxycarbonyl)amino)propanoyl)pyrrolidine-2-carboxylate

L-proline methyl ester monohydrochloride

methyl (2S)-pyrrolidine carboxylate

Downstream raw materials:

N-t-butoxycarbonyl-L-prolyl-L-alanyl-L-prolyl-α-aza-alanine benzyl ester

N^α-furylacryloyltyrosylalanylproline methyl ester

N^α-furylacryloylphenylalanylalanylproline methyl ester

N^α-furylacryloylphenylalanylalanylproline

Refernces

• 1、 Smith, Grant Gill,Evans, Robert C.,Baum, Rocky. "Neighboring Residue Effects: Evidence for Intramolecular Assistance to Racemization or Epimerization of Dipeptide Residues". . p. 7327 - 7332. Retrieved 2007/10/02.