4-[(Methylsulfonyl)oxy]-benzeneacetic acid

Base Information

• Chemical Name: 4-[(Methylsulfonyl)oxy]-benzeneacetic acid
• CAS No.: 64369-79-5
• Molecular Formula: C9H10 O5 S
• Molecular Weight: 230.24
• Hs Code.: 2916399090
• Mol file: 64369-79-5.mol

Synonyms:4-(Methanesulfonyloxy)phenylaceticacid

Chemical Property of 4-[(Methylsulfonyl)oxy]-benzeneacetic acid

Chemical Property:

• Vapor Pressure: 2.96E-08mmHg at 25°C
• Refractive Index: 1.566
• Boiling Point: 432.7°C at 760 mmHg
• Flash Point: 215.5°C
• PSA: 89.05000
• Density: 1.422g/cm³
• LogP: 1.73290
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-[4-(Methanesulfonyloxy)phenyl]aceticAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(Methylsulfonyl)oxy]-benzeneacetic acid

There total 3 articles about 4-[(Methylsulfonyl)oxy]-benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

4-[(methoxycarbonyl)methyl]phenyl mesylate (539814-10-3) → methyl 2-(4-methylsulfonyloxyphenyl)acetic acid (64369-79-5)

Guidance literature:

4-[(methoxycarbonyl)methyl]phenyl mesylate; With lithium hydroxide; water; In 1,4-dioxane; at 20 ℃; for 0.25h;

With hydrogenchloride; water; In 1,4-dioxane;

Reference yield: 80.0%

4-hydroxyphenylacetate (156-38-7) + methanesulfonyl chloride (124-63-0) → methyl 2-(4-methylsulfonyloxyphenyl)acetic acid (64369-79-5)

Guidance literature:

With sodium hydroxide; In water; at 0 - 30 ℃; pH=11 - 11.5;

DOI:10.1039/c9ob00337a

Reference yield:

→ methyl 2-(4-methylsulfonyloxyphenyl)acetic acid (64369-79-5)

Guidance literature:

entspr. Phenol, Mesylchlorid;

upstream raw materials:

4-[(methoxycarbonyl)methyl]phenyl mesylate

4-hydroxyphenylacetate

methanesulfonyl chloride

Downstream raw materials:

4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

C₂₈H₂₆Cl₃FO₇S₂

Refernces

• 1、 -. "2 -SUBSTITUTED- 3 -PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE". Page/Page column 56. . Retrieved 2008/12/08.