2-METHYLENE-1,3-DIOXEPANE

Base Information

• Chemical Name: 2-METHYLENE-1,3-DIOXEPANE
• CAS No.: 69814-56-8
• Molecular Formula: C6H10O2
• Molecular Weight: 114.144
• Hs Code.: 2932999099
• Mol file: 69814-56-8.mol

Synonyms:2-METHYLENE-1,3-DIOXEPANE;3-METHYLENE-1,3-DIOXEPANE

Chemical Property of 2-METHYLENE-1,3-DIOXEPANE

Chemical Property:

• Boiling Point: 172.8±20.0 °C(Predicted)
• PSA: 18.46000
• Density: 0.97±0.1 g/cm3(Predicted)
• LogP: 1.28460
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Methylene-1,3-dioxepane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methylene-1,3-dioxepane is used in the synthesis of functional 2-methylene-1,3-dioxepane terpolymer which functions as a building block for the construction of biodegradable pH sensitive polymeric prodrug for intracellular drug delivery.

Technology Process of 2-METHYLENE-1,3-DIOXEPANE

There total 10 articles about 2-METHYLENE-1,3-DIOXEPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

2-Chloromethyl-1,3-dioxepane (54237-96-6) + 2,6-dimethylcyclohexanol (5337-72-4,39170-83-7) → 2-methylene-1,3-dioxepane (69814-56-8)

Guidance literature:

Reference yield: 97.0%

2-(bromomethyl)-1,3-dioxepane (57626-95-6) → 2-methylene-1,3-dioxepane (69814-56-8)

Guidance literature:

With potassium tert-butylate; at 64 ℃; for 0.0833333h; Irradiation;

DOI:10.1016/0040-4039(96)00110-4

Reference yield: 96.8%

2-Chloromethyl-1,3-dioxepane (54237-96-6) + 2,4-dimethyl-3-pentanol (600-36-2) → 2-methylene-1,3-dioxepane (69814-56-8)

Guidance literature:

upstream raw materials:

2-(bromomethyl)-1,3-dioxepane

Butane-1,4-diol

chloroacetaldehyde dimethyl acetal

2-Chloromethyl-1,3-dioxepane

Downstream raw materials:

2-(phenylcarbamoylmethylidene)-1,3-dioxepane

4-acetoxybutyl benzoate

butane-1,4-diol diacetate

Refernces

• 1、 -. "IMPLANTABLE SWELLABLE BIO-RESORBABLE POLYMER". Paragraph 0244. . Retrieved 2014/02/15.
• 2、 Diaz-Ortiz, Angel,Prieto, Pilar,Loupy, Andre,Abenhaim, David. "A short and efficient synthesis of ketene O,O-and S,S-acetals under focused microwave irradiation and solvent-free conditions". . p. 1695 - 1698. Retrieved 2007/10/03.