3-ACETAMIDO-4-PICOLINE

Base Information

• Chemical Name: 3-ACETAMIDO-4-PICOLINE
• CAS No.: 52090-68-3
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 2933399090
• Mol file: 52090-68-3.mol

Synonyms:3-ACETAMIDO-4-PICOLINE

Chemical Property of 3-ACETAMIDO-4-PICOLINE

Chemical Property:

• Vapor Pressure: 0.000468mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 314.4°C at 760 mmHg
• PKA: 14.20±0.70(Predicted)
• Flash Point: 143.9°C
• PSA: 41.99000
• Density: 1.137g/cm³
• LogP: 1.42140

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-(4-Methylpyridin-3-yl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Acetamido-4-picoline is used in preparation of Phthalimide derivative with JAK inhibitory activity.

Technology Process of 3-ACETAMIDO-4-PICOLINE

There total 3 articles about 3-ACETAMIDO-4-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-amino-4-methylpyridine (3430-27-1) + acetic anhydride (108-24-7) → N-(4-methylpyridin-3-yl)acetamide (52090-68-3)

Guidance literature:

at 20 ℃; Temperature;

Reference yield:

3-nitro-4-methylpyridine (5832-44-0) → N-(4-methylpyridin-3-yl)acetamide (52090-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen sulfide; alcoholic ammonia

2: potassium carbonate; diethyl ether

With diethyl ether; hydrogen sulfide; ammonia; potassium carbonate;

Reference yield:

3-amino-4-methylpyridine (3430-27-1) + acetyl chloride (75-36-5) → N-(4-methylpyridin-3-yl)acetamide (52090-68-3)

Guidance literature:

With diethyl ether; potassium carbonate;

upstream raw materials:

3-amino-4-methylpyridine

acetyl chloride

3-nitro-4-methylpyridine

acetic anhydride

Downstream raw materials:

N-(4-formylpyridin-3-yl)acetamide

1-benzyl-4-methyl-3-amino piperidine

N-[4-(2,3,5-tri-O-benzyl-1-hydroxy-α-D-ribofuranosylmethyl)pyridin-3-yl]acetamide

3-amino-4-methylpyridine

Refernces

• 1、 -. "FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS". Paragraph 0213. . Retrieved 2016/09/22.
• 2、 -. "HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE". Page/Page column 44-45. . Retrieved 2010/04/03.