H-D-LYS(Z)-OME HCL

Base Information

• Chemical Name: H-D-LYS(Z)-OME HCL
• CAS No.: 145586-17-0
• Molecular Formula: C15H22 N2 O4
• Molecular Weight: 330.81
• Mol file: 145586-17-0.mol

Synonyms:CBZ-D-lysinemethyl ester

Chemical Property of H-D-LYS(Z)-OME HCL

Chemical Property:

• Vapor Pressure: 2.96E-09mmHg at 25°C
• Boiling Point: 470.6°C at 760 mmHg
• Flash Point: 238.4°C
• PSA: 90.65000
• LogP: 3.47660
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

H-D-Lys(Z)-OMe ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-LYS(Z)-OME HCL

There total 1 articles about H-D-LYS(Z)-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid (34404-32-5,1155-64-2,32302-83-3,57705-97-2,67178-46-5,25931-47-9) + 2,2-dimethoxy-propane (77-76-9) → Nε-benzyloxycarbonyl-D-lysine methyl ester (145586-17-0)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 18h;

DOI:10.1021/acs.jnatprod.1c00336

Reference yield: 29.0%

Nε-benzyloxycarbonyl-D-lysine methyl ester (145586-17-0) + trans-1-(3,3-diphenylpropionyl)-3-phenyl-pyrrolidine-2-carboxylic acid → (R)-6-Benzyloxycarbonylamino-2-{[(2S,3R)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester (246869-90-9) + (R)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester (246869-86-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(99)00561-X

Reference yield: 23.0%

Nε-benzyloxycarbonyl-D-lysine methyl ester (145586-17-0) + cis-1-(3,3-diphenylpropionyl)-3-phenyl-pyrrolidine-2-carboxylic acid → (R)-6-Benzyloxycarbonylamino-2-{[(2S,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester (246869-82-9) + (R)-6-Benzyloxycarbonylamino-2-{[(2R,3R)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester (246869-78-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(99)00561-X

upstream raw materials:

(R)-2-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid

2,2-dimethoxy-propane

Downstream raw materials:

N(α)-Palmitoyl-N(ε)-benzyloxycarbonyl-D-lysin-methlester

N^α-tert-butyloxycarbonyl-L-β-(uracilyl-N¹)-α-alanyl-N^ε-benzyloxycarbonyl-D-lysine methyl ester

(R)-6-Benzyloxycarbonylamino-2-{[(2S,3S)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester

(R)-6-Benzyloxycarbonylamino-2-{[(2R,3R)-1-(3,3-diphenyl-propionyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester

Refernces