2,3-Dimethylpyridin-4-amine

Base Information

• Chemical Name: 2,3-Dimethylpyridin-4-amine
• CAS No.: 122475-57-4
• Molecular Formula: C7H10 N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 818-313-3
• DSSTox Substance ID: DTXSID70428535
• Wikidata: Q82241370
• Mol file: 122475-57-4.mol

Synonyms:2,3-dimethylpyridin-4-amine;122475-57-4;4-AMINO-2,3-DIMETHYLPYRIDINE;2,3-Dimethyl-4-pyridinamine;2,3-Dimethyl-pyridin-4-ylamine;4-PYRIDINAMINE, 2,3-DIMETHYL-;dimethyl-4-aminopyridine;MFCD00030819;4-Pyridinamine,2,3-dimethyl-(9CI);SCHEMBL35248;2,3-Dimethylpyridin-4-ylamine;4-pyridinamine,2,3-dimethyl-;DTXSID70428535;YHUUZKCUQVILTK-UHFFFAOYSA-N;AKOS000269707;AB01511;CS-W002154;FS-5926;AC-27215;SY026503;2,3-Dimethyl-pyridin-4-ylamine, AldrichCPR;FT-0719148;EN300-110878;A891125

Chemical Property of 2,3-Dimethylpyridin-4-amine

Chemical Property:

• Vapor Pressure: 0.00745mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 269°C at 760 mmHg
• PKA: 10.01±0.42(Predicted)
• Flash Point: 140.7°C
• PSA: 39.64000
• Density: 1.039g/cm³
• LogP: 1.21070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 92.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dimethyl-4-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CN=C1C)N
• Uses: 2,3-Dimethyl-4-pyridinamine, can be used in the synthesis of various compounds, such as polymethylated γ-carbolines having potent anti-bovine viral diarrhea virus (BVDV) activity.

Technology Process of 2,3-Dimethylpyridin-4-amine

There total 3 articles about 2,3-Dimethylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,3-dimethyl-4-nitropyridine N-oxide (37699-43-7) → 4-amino-2,3-dimethylpyridine (122475-57-4)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; at 60 ℃; for 12h; under 2585.7 Torr;

DOI:10.1002/jhet.5570340303

Reference yield: 83.0%

2,3-dimethyl-4-nitropyridine N-oxide (37699-43-7) → C7H10N2O + 4-amino-2,3-dimethylpyridine (122475-57-4)

Guidance literature:

With hydrogenchloride; titanium(III) chloride; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/acs.oprd.5b00312

Reference yield:

2,3-dimethylpyridine 1-oxide (22710-07-2,166521-76-2) → 4-amino-2,3-dimethylpyridine (122475-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / H₂SO₄, HNO₃ / 5 h / 100 °C

2: 94 percent / H₂, gl. AcOH / 10percent Pd/C / 12 h / 60 °C / 2585.7 Torr

With sulfuric acid; hydrogen; nitric acid; acetic acid; palladium on activated charcoal;

DOI:10.1002/jhet.5570340303

upstream raw materials:

2,3-dimethyl-4-nitropyridine N-oxide

2,3-dimethylpyridine 1-oxide

Downstream raw materials:

C₁₃H₁₃BrN₂

1,6,7-Trimethyl-1H-imidazo[4,5-c]pyridin-2-ylamine

2,3-dimethyl-4-methylaminopyridine

Refernces

• 1、 Aoyama, Hiroshi,Sako, Kumiko,Sato, Shinichi,Nakamura, Masahiko,Miyachi, Hiroyuki,Goto, Yukinori,Okamoto, Mika,Baba, Masanori,Hashimoto, Yuichi. "Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity". scheme or table. p. 779 - 785. Retrieved 2010/09/18.
• 2、 Hirayama, Fukushi,Konno, Katsuhiro,Shirahama, Haruhisa,Matsumoto, Takeshi. "4-AMINOPYRIDINE-2,3-DICARBOXYLIC ACID FROM CLITOCYBE ACROMELALGA". . p. 1133 - 1136. Retrieved 2007/10/02.