1-(2,4-DICHLOROBENZYL)PIPERAZINE

Base Information

• Chemical Name: 1-(2,4-DICHLOROBENZYL)PIPERAZINE
• CAS No.: 51619-56-8
• Molecular Formula: C11H14Cl2N2
• Molecular Weight: 245.152
• Hs Code.: 2933599090
• Mol file: 51619-56-8.mol

Synonyms:1-(2,4-Dichlorobenzyl)piperazine;AKOS MSC-0731;AKOS B014421;

Chemical Property of 1-(2,4-DICHLOROBENZYL)PIPERAZINE

Chemical Property:

• Vapor Pressure: 0.000146mmHg at 25°C
• Refractive Index: n20/D 1.571
• Boiling Point: 332.4 °C at 760 mmHg
• PKA: 9.03±0.10(Predicted)
• Flash Point: 154.8 °C
• PSA: 15.27000
• Density: 1.252 g/cm³
• LogP: 2.66530

Purity/Quality:

99% ^*data from raw suppliers

1-(2,4-Dichlorobenzyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4-DICHLOROBENZYL)PIPERAZINE

There total 4 articles about 1-(2,4-DICHLOROBENZYL)PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

piperazine (110-85-0) + 2,4-Dichlorobenzyl chloride (94-99-5) → 1-(2,4-dichlorobenzyl)piperazine (51619-56-8)

Guidance literature:

In tetrahydrofuran; for 4h; Reflux;

DOI:10.1016/j.ejmech.2011.01.020

Reference yield:

1-(2,4-dichlorobenzyl)-4-Boc-piperazine → 1-(2,4-dichlorobenzyl)piperazine (51619-56-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

2,4-dichlorobenzaldeyhde (874-42-0) → 1-(2,4-dichlorobenzyl)piperazine (51619-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.5 h

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With trifluoroacetic acid; In methanol; dichloromethane;

upstream raw materials:

piperazine

2,4-Dichlorobenzyl chloride

2,4-dichlorobenzaldeyhde

Refernces

• 1、 El-wahab, Hend A.A. Abd,Accietto, Mauro,Marino, Leonardo B.,McLean, Kirsty J.,Levy, Colin W.,Abdel-Rahman, Hamdy M.,El-Gendy, Mahmoud A.,Munro, Andrew W.,Aboraia, Ahmed S.,Simons, Claire. "Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics". . p. 161 - 176. Retrieved 2017/11/29.
• 2、 Wang, Bao-Lei,Zhang, Li-Yuan,Zhan, Yi-Zhou,Zhang, Yan,Zhang, Xiao,Wang, Li-Zhong,Li, Zheng-Ming. "Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties". . p. 36 - 44. Retrieved 2018/03/27.