4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide

Base Information

• Chemical Name: 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide
• CAS No.: 1030633-38-5
• Molecular Formula: BrH*C₂₀H₁₅BrN₆O
• Molecular Weight: 516.195
• Mol file: 1030633-38-5.mol

Synonyms:4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide

Chemical Property of 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

ETRAVIRINE HYDROBROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide

There total 3 articles about 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{6-amino-2-[(4-cyanophenyl)amino]pyrimidin-4-yloxy}-3,5-dimethylbenzenecarbonitrile → 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide (1030633-38-5) + etravirine (269055-15-4,394729-17-0)

Guidance literature:

4-{6-amino-2-[(4-cyanophenyl)amino]pyrimidin-4-yloxy}-3,5-dimethylbenzenecarbonitrile; With bromine; acetic acid; at 20 - 80 ℃; for 4.25h;

With sodium hydroxide; In water; at 20 ℃;

Reference yield:

etravirine (269055-15-4,394729-17-0) → 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide (1030633-38-5)

Guidance literature:

With hydrogen bromide; In dichloromethane; water;

Reference yield:

4-{6-amino-2-[(4-cyanophenyl)amino]pyrimidin-4-yloxy}-3,5-dimethylbenzenecarbonitrile → 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile hydrobromide (1030633-38-5)

Guidance literature:

With bromine; acetic acid; at 20 ℃;

upstream raw materials:

etravirine

Downstream raw materials:

etravirine

Refernces

• 1、 -. "HYDROBROMIDE SALT OF AN ANTI-HIV COMPOUND". Page/Page column 10. . Retrieved 2008/12/06.