8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 947499-03-8
• Molecular Formula: C₁₀H₁₂BrN
• Molecular Weight: 226.116
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID10693124
• Wikidata: Q82622144
• Mol file: 947499-03-8.mol

Synonyms:947499-03-8;8-BROMO-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE;8-bromo-2-methyl-3,4-dihydro-1H-isoquinoline;8-BROMO-2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;ISOQUINOLINE,8-BROMO-1,2,3,4-TETRAHYDRO-2-METHYL-;SCHEMBL3117967;DTXSID10693124;HEVSJNXWDZDGHL-UHFFFAOYSA-N;AKOS022182125;SB40169;CS-0144533;8-bromanyl-2-methyl-3,4-dihydro-1H-isoquinoline;A845082

Chemical Property of 8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• PSA: 3.24000
• LogP: 2.37490
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 225.01531
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

8-Bromo-2-methyl-1,2,3,4-tetrahydro-isoquinoline 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=C(C1)C(=CC=C2)Br

Technology Process of 8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-methyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine (14788-34-2) → 8-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline (947499-03-8)

Guidance literature:

2-methyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine; With hydrogen bromide; copper(I) bromide; sodium nitrite; In water; at 0 ℃; for 3.16667h;

With sodium hydroxide; In water; pH=9;

upstream raw materials:

2-methyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine

Refernces

• 1、 -. "CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY". Page/Page column 70. . Retrieved 2010/04/03.
• 2、 -. "4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY". Page/Page column 88. . Retrieved 2010/04/06.