5-AMINO-1,3-DIHYDROXYMETHYLBENZENE

Base Information

• Chemical Name: 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE
• CAS No.: 71176-54-0
• Molecular Formula: C8H11 N O2
• Molecular Weight: 153.181
• Hs Code.: 2922199090
• Mol file: 71176-54-0.mol

Synonyms:3,5-Bis(hydroxymethyl)aniline;3-Amino-5-(hydroxymethyl)benzyl alcohol; 5-Amino-1,3-benzenedimethanol;[3-Amino-5-(hydroxymethyl)phenyl]methanol

Chemical Property of 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE

Chemical Property:

• Melting Point: 98 °C
• Boiling Point: 388.5±32.0 °C(Predicted)
• PKA: 14.16±0.10(Predicted)
• PSA: 66.48000
• Density: 1.283±0.06 g/cm3(Predicted)
• LogP: 0.83460
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

(5-Amino-1,3-phenylene)dimethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (5-Amino-1,3-phenylene)dimethanol is a useful research chemical, a reagent in the synthesis of nucleic acid analogs consisting of a benzene-phosphate backbone.

Technology Process of 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE

There total 10 articles about 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-nitro-m-xylene-(α,α')-diol (71176-55-1) → (3-amino-5-hydroxymethylphenyl)methanol (71176-54-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2h; under 258.581 Torr;

Reference yield: 96.0%

dimethyl 5-aminoisophthalate (99-27-4) → (3-amino-5-hydroxymethylphenyl)methanol (71176-54-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 14h; Heating;

DOI:10.1002/adsc.200404264

Reference yield: 96.0%

diethyl 5-aminoisophthalate (42122-73-6) → (3-amino-5-hydroxymethylphenyl)methanol (71176-54-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; Reflux; Inert atmosphere;

DOI:10.1002/ejic.201700365

upstream raw materials:

5-aminoisophthalic acid

diethyl 5-nitro-isophthalate

5-nitro-m-xylene-(α,α')-diol

diethyl 5-aminoisophthalate

Downstream raw materials:

3,5-bis(hydroxymethyl)benzonitrile

3-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(hydroxymethyl)benzonitrile

(3-(aminomethyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)phenyl)methanol

N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine

Refernces

• 1、 Metherell, Alexander J.,Ward, Michael D.. "Coordination chemistry of an amine-substituted bis(pyrazolyl)-pyridine ligand: interaction of a peripheral functional group on a coordination cage with the internal contents of the cavity". . p. 822 - 831. Retrieved 2018.
• 2、 -. "THERAPEUTIC METHODS". Page/Page column 97-98; 102-103; 106; 109. . Retrieved 2020/05/28.
• 3、 -. "TARGETED COMPOSITIONS". Page/Page column 86; 90; 91; 94; 97. . Retrieved 2018/11/10.