ethyl [2-¹³C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate

Base Information

• Chemical Name: ethyl [2-¹³C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate
• CAS No.: 1607788-53-3
• Molecular Formula: C₁₅H₂₂O₄
• Molecular Weight: 267.326
• Mol file: 1607788-53-3.mol

Synonyms:ethyl [2-¹³C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate

Chemical Property of ethyl [2-¹³C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl [2-¹³C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate

There total 1 articles about ethyl [2-¹³C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl <2-13C>acetate (58735-82-3) + 4-(benzyloxy)-2-butanone (6278-91-7) → ethyl [2-13C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate (1607788-53-3)

Guidance literature:

ethyl <2-13C>acetate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

4-(benzyloxy)-2-butanone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c3cc45982a

Reference yield: 71.0%

ethyl [2-13C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate (1607788-53-3) → tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one-13C (53771-22-5)

Guidance literature:

ethyl [2-¹³C]-5-(benzyloxy)-3-hydroxy-3-methylpentanoate; With palladium on activated charcoal; hydrogen;

With toluene-4-sulfonic acid;

DOI:10.1021/acs.orglett.6b02569

upstream raw materials:

ethyl <2-13C>acetate

4-(benzyloxy)-2-butanone

Downstream raw materials:

tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one-¹³C

Refernces

• 1、 Citron, Christian A.,Brock, Nelson L.,Tudzynski, Bettina,Dickschat, Jeroen S.. "Labelling studies on the biosynthesis of terpenes in Fusarium fujikuroi". . p. 5224 - 5226. Retrieved 2014.