METHYL 4-AMINO-2-FLUOROBENZOATE

Base Information

• Chemical Name: METHYL 4-AMINO-2-FLUOROBENZOATE
• CAS No.: 73792-08-2
• Molecular Formula: C8H8FNO2
• Molecular Weight: 169.155
• Hs Code.: 2922499990
• Mol file: 73792-08-2.mol

Synonyms:Methyl 4-amino-2-fluorobenzoate;Methyl 2-fluoro-4-aminobenzoate;2-Fluoro-4-aminobenzoicacid methyl ester;

Chemical Property of METHYL 4-AMINO-2-FLUOROBENZOATE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.544
• Boiling Point: 302.319 °C at 760 mmHg
• PKA: 1.45±0.10(Predicted)
• Flash Point: 136.638 °C
• PSA: 52.32000
• Density: 1.264 g/cm³
• LogP: 1.77570
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl4-amino-2-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-AMINO-2-FLUOROBENZOATE

There total 8 articles about METHYL 4-AMINO-2-FLUOROBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-fluoro-4-nitro-benzoic acid methyl ester (392-09-6) → methyl 4-amino-2-fluorobenzoate (73792-08-2)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1016/j.bmc.2009.05.037

Reference yield: 98.0%

→ methyl 4-amino-2-fluorobenzoate (73792-08-2)

Guidance literature:

Reference yield: 95.5%

methanol (67-56-1) + 2-fluoro-4-aminobenzoic acid (446-31-1) → methyl 4-amino-2-fluorobenzoate (73792-08-2)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

upstream raw materials:

2-fluoro-4-nitro-benzoic acid methyl ester

methyl 4-azido-2-fluorobenzoate

diethylamine

toluene

Downstream raw materials:

methyl 2-fluoro-4-{[(2-fluorophenyl)carbonyl]amino}benzoate

2-fluoro-4-methylamino benzoic acid methyl ester

methyl 2-fluoro-4-[(pyridin-2-ylcarbonyl)amino]benzoate

4-(3,5-diisopropoxy-4-ethoxybenzamido)-2-fluorobenzoic acid

Refernces

• 1、 -. "INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR". Paragraph 0384-0385. . Retrieved 2019/06/07.
• 2、 -. "Compound and composition as well as application thereof to drugs preparation". Paragraph 0109; 0112-0114. . Retrieved 2019/01/08.