methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate

Base Information

• Chemical Name: methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate
• CAS No.: 356783-27-2
• Molecular Formula: C₆H₅FN₂O₃
• Molecular Weight: 172.116
• Mol file: 356783-27-2.mol

Synonyms:methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate

Chemical Property of methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate

Chemical Property:

• Density: 1.52±0.1 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Methyl6-fluoro-3-hydroxypyrazine-2-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 6-fluoro-3-hydroxypyrazine-2-carboxylate is a building block related to Favipiravir(F103350). Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever.

Technology Process of methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate

There total 1 articles about methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3,6-difluoropyrazine-2-carboxylate (356783-26-1) → methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate (356783-27-2)

Guidance literature:

With sodium chloride; sodium acetate; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate (356783-27-2) → favipiravir (259793-96-9)

Guidance literature:

With sodium bicarbonate; sodium chloride; ammonia; In methanol; water; ethyl acetate;

upstream raw materials:

methyl 3,6-difluoropyrazine-2-carboxylate

Downstream raw materials:

favipiravir

Refernces