2-(3,5-DIFLUOROPHENYL)ACETOHYDRAZIDE

Base Information

• Chemical Name: 2-(3,5-DIFLUOROPHENYL)ACETOHYDRAZIDE
• CAS No.: 797784-29-3
• Molecular Formula: C8H8F2N2O
• Molecular Weight: 186.161
• Hs Code.: 2928000090
• Mol file: 797784-29-3.mol

Synonyms:3,5-Difluorobenzeneacetohydrazide;

Chemical Property of 2-(3,5-DIFLUOROPHENYL)ACETOHYDRAZIDE

Chemical Property:

• Vapor Pressure: 5.48E-05mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 347.2 °C at 760 mmHg
• Flash Point: 163.8 °C
• PSA: 58.61000
• Density: 1.327 g/cm³
• LogP: 2.03780
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Difluorophenylaceticacidhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,5-DIFLUOROPHENYL)ACETOHYDRAZIDE

There total 6 articles about 2-(3,5-DIFLUOROPHENYL)ACETOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-(3,5-difluorophenyl)acetate (210530-70-4) → 2-(3,5-difluorophenyl)acetic hydrazide (797784-29-3)

Guidance literature:

With hydrazine hydrate; In methanol; for 2h; Reflux;

Reference yield: 46.0%

2-(3,5-difluorophenyl)acetic hydrazide hydrochloride → 2-(3,5-difluorophenyl)acetic hydrazide (797784-29-3)

Guidance literature:

With triethylamine; at 20 ℃; for 0.5h;

DOI:10.1039/d1md00044f

Reference yield: 46.0%

→ 2-(3,5-difluorophenyl)acetic hydrazide (797784-29-3)

Guidance literature:

With triethylamine; at 20 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

3,5-difluorophenyl acetic acid

ethyl 2-(3,5-difluorophenyl)acetate

methyl 2-(3,5-difluorophenyl)acetate

Refernces

• 1、 Crider, A. Michael,Farr, Susan A.,Frare, Rafael,Hospital, Audrey,Kontoyianni, Maria,Kukielski, Stephen G.,Minaeian, Mahsa,Mobayen, Shirin,Neumann, William L.,Niehoff, Michael L.,Sandoval, Karin E.,Slater, Olivia,Srabony, Khush N.,Witt, Ken A.. "Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: High affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment". . p. 1352 - 1365. Retrieved 2021/11/09.
• 2、 -. "3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF". Paragraph 0158; 0193; 0203. . Retrieved 2018/12/02.