3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester

Base Information

• Chemical Name: 3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester
• CAS No.: 863667-14-5
• Molecular Formula: C₂₀H₂₇NO₅
• Molecular Weight: 361.438
• Mol file: 863667-14-5.mol

Synonyms:3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester

Chemical Property of 3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester

There total 2 articles about 3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-benzyloxycarbonylamino-3-(pyridin-2-ylsulfanylcarbonyl)propionic acid tert-butyl ester (863667-11-2) + cyclobutylmagnesium bromide (13384-48-0) → 3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester (863667-14-5)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at -8 ℃;

DOI:10.1021/ol051287d

Reference yield:

Z-D(tBu)-OH (5545-52-8) → 3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester (863667-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C

2: 50 percent / CuI / tetrahydrofuran / -8 °C

With copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol051287d

upstream raw materials:

3-benzyloxycarbonylamino-3-(pyridin-2-ylsulfanylcarbonyl)propionic acid tert-butyl ester

cyclobutylmagnesium bromide

Z-D(tBu)-OH

Refernces