5,6-Dichloropicolinic acid

Base Information

• Chemical Name: 5,6-Dichloropicolinic acid
• CAS No.: 88912-24-7
• Molecular Formula: C6H3 Cl2 N O2
• Molecular Weight: 192.001
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30534141
• Wikidata: Q82407801
• Mol file: 88912-24-7.mol

Synonyms:5,6-Dichloropicolinic acid;88912-24-7;5,6-dichloropyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 5,6-dichloro-;2,3-DICHLORO-6-CARBOXYPYRIDINE;5,6-Dichloro-2-pyridinecarboxylic acid;MFCD13185546;FURFURYLPENTANOATE;5,6- dichloropicolinic acid;SCHEMBL3632915;DTXSID30534141;5 pound not6-Dichloropicolinic acid;2,3-dichloro-6-pyridinecarboxylicacid;AKOS015999456;AM62362;CS-W009205;GS-3701;5,6-Dichloro-pyridine-2-carboxylic acid;SY112665;A26078

Chemical Property of 5,6-Dichloropicolinic acid

Chemical Property:

• Boiling Point: 342.1±37.0 °C(Predicted)
• PKA: 3.04±0.10(Predicted)
• PSA: 50.19000
• Density: 1.612±0.06 g/cm3(Predicted)
• LogP: 2.08660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 190.9540837
• Heavy Atom Count: 11
• Complexity: 165

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6-Dichloropicolinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1Cl)Cl)C(=O)O

Technology Process of 5,6-Dichloropicolinic acid

There total 3 articles about 5,6-Dichloropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-chloropicolinic acid N-oxide (1415898-80-4) → 5,6-dichloro-2-pyridinecarboxylic acid (88912-24-7)

Guidance literature:

With trichlorophosphate; at 0 - 95 ℃; for 1h;

Reference yield:

2,3-dichloro-6-(trichloromethyl)pyridine (51492-01-4) → 5,6-dichloro-2-pyridinecarboxylic acid (88912-24-7)

Guidance literature:

With sulfuric acid; In sulfolane; at 50 - 130 ℃;

DOI:10.1021/op5001258

Reference yield:

5-chloropicolinic acid (86873-60-1) → 5,6-dichloro-2-pyridinecarboxylic acid (88912-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 40 °C

2: trichlorophosphate / 1 h / 0 - 95 °C

With 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane;

upstream raw materials:

5-chloropicolinic acid

5-chloropicolinic acid N-oxide

2,3-dichloro-6-(trichloromethyl)pyridine

Downstream raw materials:

isopropyl 5-fluoro-6-phenylpicolinate

iso-propyl 5-chloro-6-phenylpicolinate

2,3-diethylthiopyridine

2,3-bis(methylthio)pyridine

Refernces

• 1、 -. "NOVEL PYRIDINE DERIVATIVES". . . Retrieved 2013/02/27.