8-N-BOC-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-2-PROPOINIC ACID

Base Information

• Chemical Name: 8-N-BOC-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-2-PROPOINIC ACID
• CAS No.: 886362-45-4
• Molecular Formula: C16H22N2O4
• Molecular Weight: 306.362
• Hs Code.: 2933990090
• Mol file: 886362-45-4.mol

Synonyms:1,8-Naphthyridine-2-propanoicacid, 8-[(1,1-dimethylethoxy)carbonyl]-5,6,7,8-tetrahydro- (9CI);8-N-Boc-5,6,7,8-Tetrahydro-1,8-naphthyridin-2-propoinic acid;

Chemical Property of 8-N-BOC-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-2-PROPOINIC ACID

Chemical Property:

• Vapor Pressure: 9.31E-10mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 473.1 °C at 760 mmHg
• Flash Point: 239.9 °C
• PSA: 79.73000
• Density: 1.217 g/cm³
• LogP: 2.85150
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-(8-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-N-BOC-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-2-PROPOINIC ACID

There total 5 articles about 8-N-BOC-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-2-PROPOINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

tert-butyl 7-(3-ethoxy-3-oxopropyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate (1272758-04-9) → 3-(8-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoic acid (886362-45-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 28 ℃; for 16h; Inert atmosphere;

Reference yield:

ethyl 3-(1,8-naphthyridin-2-yl)propionate (495419-56-2) → 3-(8-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoic acid (886362-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 16 h / 28 °C / 750.08 Torr

2: 16 h / 75 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 28 °C / Inert atmosphere

With 5%-palladium/activated carbon; water; hydrogen; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

Reference yield:

ethyl 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoate (312262-99-0) → 3-(8-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoic acid (886362-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 h / 75 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 28 °C / Inert atmosphere

With water; lithium hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

ethyl 3-(1,8-naphthyridin-2-yl)propionate

ethyl 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoate

tert-butyl 7-(3-ethoxy-3-oxopropyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate

2-Aminonicotinaldehyde

Refernces

• 1、 -. "CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS". . . Retrieved 2018/05/27.