5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole

Base Information

• Chemical Name: 5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole
• CAS No.: 869336-36-7
• Molecular Formula: C₁₈H₁₃N₃
• Molecular Weight: 271.321
• Mol file: 869336-36-7.mol

Synonyms:5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole

Chemical Property of 5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole

There total 4 articles about 5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

β-(1-naphthyl)nitroethylene (37630-26-5,4735-49-3) + Phenyl azide (622-37-7) → 5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole (869336-36-7)

Guidance literature:

With bismuth tungstate; In water; at 80 ℃; for 5h; regioselective reaction;

DOI:10.1039/c5ra09544a

Reference yield: 78.0%

1-phenyl-1,2,3-triazole (1453-81-2) + 1-Iodonaphthalene (90-14-2) → 5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole (869336-36-7)

Guidance literature:

With C₁₈H₁₆N₂O₄Pd; caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 12h; regioselective reaction;

DOI:10.1080/00397911.2017.1381260

Reference yield: 58.0%

1-ethynylnaphthalene (15727-65-8) + Phenyl azide (622-37-7) → 5-(naphthalen-1-yl)-1-phenyl-1H-1,2,3-triazole (869336-36-7)

Guidance literature:

1-ethynylnaphthalene; With ethylmagnesium bromide; In tetrahydrofuran; at 20 - 50 ℃; for 0.25h;

Phenyl azide; In tetrahydrofuran; at 20 - 50 ℃; for 1.5h;

DOI:10.1021/ol051844w

upstream raw materials:

1-ethynylnaphthalene

Phenyl azide

β-(1-naphthyl)nitroethylene

1-phenyl-1,2,3-triazole

Refernces

• 1、 Markandeya, Sarma V.,Renuka, Ch.,Lakshmi, Parvathi K.,Rajesh,Sridhar, Chidara,Babu, Korupolu Raghu. "Design and applications of new phosphine-free tetradentate Pd-catalyst: Regioselective C–H activation on 1-substituted 1,2,3-triazoles and indoles(NH-Free)". supporting information. p. 135 - 145. Retrieved 2017/12/28.
• 2、 Dai, Qian,Gao, Wenzhong,Liu, Duan,Kapes, Lea M.,Zhang, Xumu. "Triazole-based monophosphine ligands for palladium-catalyzed cross-coupling reactions of aryl chlorides". . p. 3928 - 3934. Retrieved 2007/10/03.