(S)-naproxen di(1-naphthyl)methyl ester

Base Information

• Chemical Name: (S)-naproxen di(1-naphthyl)methyl ester
• CAS No.: 1116086-50-0
• Molecular Formula: C₃₅H₂₈O₃
• Molecular Weight: 496.606
• Mol file: 1116086-50-0.mol

Synonyms:(S)-naproxen di(1-naphthyl)methyl ester

Chemical Property of (S)-naproxen di(1-naphthyl)methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-naproxen di(1-naphthyl)methyl ester

There total 2 articles about (S)-naproxen di(1-naphthyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

naproxen (23981-80-8) + bis(1-naphthyl)methanol (62784-66-1) → (S)-naproxen di(1-naphthyl)methyl ester (1116086-50-0) + (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-2-(6-methoxy-2-naphthyl)propionic acid (23979-41-1)

Guidance literature:

With (-)-(S)-β-Np-BTM; p-Methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; optical yield given as %ee; Resolution of racemate;

DOI:10.1002/ejoc.200800942

Reference yield:

naproxen (23981-80-8) + bis(1-naphthyl)methanol (62784-66-1) → (R)-naproxen di(1-naphthyl)methyl ester + (S)-naproxen di(1-naphthyl)methyl ester (1116086-50-0) + (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-2-(6-methoxy-2-naphthyl)propionic acid (23979-41-1)

Guidance literature:

With (S)-2-(naphthalen-1-yl)-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; p-Methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; optical yield given as %ee; Resolution of racemate;

DOI:10.1002/ejoc.200800942

Reference yield: 85.0%

(S)-naproxen di(1-naphthyl)methyl ester (1116086-50-0) → (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1)

Guidance literature:

With palladium on carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 26h; optical yield given as %ee;

DOI:10.1021/ja103490h

upstream raw materials:

naproxen

bis(1-naphthyl)methanol

Downstream raw materials:

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

Refernces

• 1、 -. "METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID". Page/Page column 13-14. . Retrieved 2010/09/18.