2-Chloro-6-methyl-benzoic acid methyl ester

Base Information

• Chemical Name: 2-Chloro-6-methyl-benzoic acid methyl ester
• CAS No.: 99585-14-5
• Molecular Formula: C9H9 Cl O2
• Molecular Weight: 184.622
• Hs Code.: 2916399090
• Mol file: 99585-14-5.mol

Synonyms:o-Toluicacid, 6-chloro-, methyl ester (6CI); 2-Chloro-6-methylbenzoic acid methylester; Methyl 2-chloro-6-methylbenzoate

Chemical Property of 2-Chloro-6-methyl-benzoic acid methyl ester

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.00% ^*data from raw suppliers

Methyl2-Chloro-6-Methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6-methyl-benzoic acid methyl ester

There total 7 articles about 2-Chloro-6-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + 2-chloro-6-methylbenzoyl chloride (89894-44-0) → methyl 2-chloro-6-methylbenzoate (99585-14-5)

Guidance literature:

methanol; 2-chloro-6-methylbenzoyl chloride; In dichloromethane; at 0 ℃; for 0.75h;

With triethylamine; at 20 ℃;

Reference yield: 14.0%

methanol (67-56-1) + 2-chloro-6-methylbenzenediazonium tetrafluoroborate (85070-46-8) + carbon monoxide (201230-82-2) → 1-chloro-3-methylbenzene (108-41-8) + methyl 2-chloro-6-methylbenzoate (99585-14-5)

Guidance literature:

With base; Pd-catalyst; under 30003 Torr; Inert atmosphere; Autoclave; Heating;

DOI:10.1021/op0102363

Reference yield:

2-chloro-6-methylbenzoic acid (21327-86-6) + methyl iodide (74-88-4) → methyl 2-chloro-6-methylbenzoate (99585-14-5)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 3h;

upstream raw materials:

2-chloro-6-methylbenzoic acid

methyl iodide

methanol

2-chloro-6-methylbenzoyl chloride

Downstream raw materials:

2-chloro-6-methylbenzoic acid

2-chloro-6-methylbenzoyl chloride

methyl 2-chloro-4-hydroxy-6-methylbenzoate

methyl 2-(bromomethyl)-6-chlorobenzoate

Refernces

• 1、 -. "Substituted Spiro-amide Compounds". Page/Page column 91. . Retrieved 2010/10/19.
• 2、 -. "PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK' S AND GSK' S". Page/Page column 149-150. . Retrieved 2008/06/13.