(4-thien-2-yltetrahydropyran-4-yl)methylamine

Base Information

• Chemical Name: (4-thien-2-yltetrahydropyran-4-yl)methylamine
• CAS No.: 906422-74-0
• Molecular Formula: C₁₀H₁₅NOS
• Molecular Weight: 197.301
• Hs Code.: 2932990090
• Mol file: 906422-74-0.mol

Synonyms:(4-thien-2-yltetrahydropyran-4-yl)methylamine;4-(Aminomethyl)-4-thien-2-yltetahydropyran 97%;4-(Aminomethyl)-4-thien-2-yltetahydropyran

Chemical Property of (4-thien-2-yltetrahydropyran-4-yl)methylamine

Chemical Property:

• Vapor Pressure: 0.000492mmHg at 25°C
• Refractive Index: 1.551
• Boiling Point: 313.6°Cat760mmHg
• Flash Point: 143.4°C
• PSA: 63.49000
• Density: 1.131g/cm³
• LogP: 2.45530

Purity/Quality:

98% ^*data from raw suppliers

4-(Aminomethyl)-4-(thien-2-yl)tetrahydro-2H-pyran 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-thien-2-yltetrahydropyran-4-yl)methylamine

There total 2 articles about (4-thien-2-yltetrahydropyran-4-yl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

4-thiophen-2-yltetrahydropyran-4-carbonitrile (880166-17-6) → C-(4-thiophen-2-yltetrahydropyran-4-yl)methylamine (906422-74-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; benzene; for 5h; Reflux;

DOI:10.1016/j.bmcl.2017.10.055

Reference yield:

2-cyanomethylthiophene (20893-30-5) → C-(4-thiophen-2-yltetrahydropyran-4-yl)methylamine (906422-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 50 °C

2: lithium aluminium tetrahydride / benzene; diethyl ether / 5 h / Reflux

With lithium aluminium tetrahydride; sodium hydroxide; In diethyl ether; benzene;

DOI:10.1016/j.bmcl.2017.10.055

upstream raw materials:

2-cyanomethylthiophene

4-thiophen-2-yltetrahydropyran-4-carbonitrile

Refernces