2,3,5-Trichloropyridin-4-amine

Base Information

• Chemical Name: 2,3,5-Trichloropyridin-4-amine
• CAS No.: 28443-69-8
• Molecular Formula: C5H3 Cl3 N2
• Molecular Weight: 197.451
• Hs Code.: 2933399090
• European Community (EC) Number: 631-116-5
• DSSTox Substance ID: DTXSID40352530
• Wikidata: Q82129726
• Mol file: 28443-69-8.mol

Synonyms:2,3,5-trichloropyridin-4-amine;28443-69-8;4-Amino-2,3,5-trichloropyridine;2,3,5-Trichloro-4-pyridinamine;4-AMINO-2,3,5-TRICHLOROPYRIDINE, 98;AC-907/30002043;SCHEMBL4375909;DTXSID40352530;YYJDUYUWQJWYNA-UHFFFAOYSA-N;2,3,5-trichloro-4-pyridinylamine;MFCD00153908;AKOS001026905;DS-2444;CS-0157876;FT-0710829;F12169;EN300-1267340;SR-01000389665;SR-01000389665-1

Chemical Property of 2,3,5-Trichloropyridin-4-amine

Chemical Property:

• Vapor Pressure: 0.00163mmHg at 25°C
• Melting Point: 153-155 °C(lit.)
• Refractive Index: 1.635
• Boiling Point: 294.4oC at 760 mmHg
• PKA: -0.83±0.10(Predicted)
• Flash Point: 131.8oC
• PSA: 38.91000
• Density: 1.634g/cm3
• LogP: 3.20520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.936181
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3,5-Trichloropyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(C(=N1)Cl)Cl)N)Cl
• Uses: 2,3,5-Trichloropyridin-4-amine can be used inhibitors of PDE4.

Technology Process of 2,3,5-Trichloropyridin-4-amine

There total 3 articles about 2,3,5-Trichloropyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

4-amino-3,5,6-trichloro-2-trichloromethylpyridine (5005-62-9) → 4-amino-2,3,5-trichloropyridine (28443-69-8) + picloram (1918-02-1)

Guidance literature:

With sulfuric acid; trichloroacetic acid; In water; at 110 ℃; for 10h;

Reference yield:

2,4-Dichlorophenoxyacetic acid (94-75-7,89300-30-1) + picloram (1918-02-1) → 4-aminopyridine-2-carboxylic acid (100047-36-7) + 2-Chloro-1,4-benzoquinone (695-99-8) + 4-amino-2,3,5-trichloropyridine (28443-69-8) + chloro-p-hydroquinone (615-67-8) + 2,4-dichlorophenol (120-83-2,40477-79-0)

Guidance literature:

With ammonium hydroxide; In water; Catalytic behavior; Irradiation;

DOI:10.1039/c4pp00273c

Reference yield:

2,3,5-trichloropyridine (55934-01-5) → 4-amino-2,3,5-trichloropyridine (28443-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NH₃ / 160 °C

2: concentrated aqueous HCl; aqueous H₂O₂

With hydrogenchloride; ammonium hydroxide; dihydrogen peroxide;

upstream raw materials:

4-amino-3,5,6-trichloro-2-trichloromethylpyridine

2,3,5-trichloropyridine

2,4-Dichlorophenoxyacetic acid

picloram

Downstream raw materials:

2,3,5-Trichloro-4-pyridinol

2,3,5,6-tetrachloro-pyridin-4-ylamine

Refernces

• 1、 Litvineneko, G. S.,Ovchinnikov, V. G.,Lobanova, I. A.,Maksimenko, N. M.,Zatsarevnyi, V. M.. "HYDROLYSIS OF 4-AMINO-3,5,6-TRICHLORO-2-TRICHLOROMETHYLPYRIDINE IN TRICHLOROACETIC ACID". . p. 824 - 830. Retrieved 2007/10/02.