4,5-Diaminopyrimidin-2-ol

Base Information

• Chemical Name: 4,5-Diaminopyrimidin-2-ol
• CAS No.: 23899-73-2
• Molecular Formula: C4H6 N4 O
• Molecular Weight: 126.118
• Hs Code.: 2933599090
• European Community (EC) Number: 868-862-8
• Nikkaji Number: J1.397.387C
• ChEMBL ID: CHEMBL2151971
• Mol file: 23899-73-2.mol

Synonyms:5-aminocytosine

Chemical Property of 4,5-Diaminopyrimidin-2-ol

Chemical Property:

• PSA: 97.79000
• LogP: 0.09670
• XLogP3: -1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 126.05416083
• Heavy Atom Count: 9
• Complexity: 205

Purity/Quality:

98% ^*data from raw suppliers

4,5-Diaminopyrimidin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC(=O)NC(=C1N)N

Technology Process of 4,5-Diaminopyrimidin-2-ol

There total 6 articles about 4,5-Diaminopyrimidin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-amino-5-nitropyrimidin-2(1H)-one (69099-99-6) → 4,5-diamino-1,2-dihydropyrimidin-2-one (23899-73-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; at 20 ℃; for 3h; under 2844.39 Torr;

DOI:10.1002/anie.200603209

Reference yield:

→ 4,5-diamino-1,2-dihydropyrimidin-2-one (23899-73-2)

Guidance literature:

With aluminium amalgam; water;

Reference yield:

→ 4,5-diamino-1,2-dihydropyrimidin-2-one (23899-73-2)

Guidance literature:

With sulfuric acid;

DOI:10.1039/jr9540002060

upstream raw materials:

4-amino-5-nitropyrimidin-2(1H)-one

1,3-dihydro-2H-purin-2-one

sulfuric acid

water

Downstream raw materials:

5-hydroxyuracil

1,3,6,8-tetrahydro-2,4,5,7-pyrimido<5,4-g>pteridinetetrone

1,6-dihydropyrimido[4,5-g]pteridine-2,4,7,9(3H,8H)-tetraone

5-Aminouracil

Refernces

• 1、 Mittapalli, Gopi Kumar,Osornio, Yazmin M.,Guerrero, Miguel A.,Reddy, Kondreddi Ravinder,Krishnamurthy, Ramanarayanan,Eschenmoser, Albert. "Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements". . p. 2478 - 2484. Retrieved 2008/03/11.
• 2、 Andresen, Geir,Gundersen, Lise-Lotte,Lundmark, Max,Rise, Frode,Sundell, Staffan. "Regioselective Addition of Grignard Reagents to a 2-Oxopurinium Salt". . p. 3655 - 3664. Retrieved 2007/10/02.