4-CHLORO-3-IODOPHENOL

Base Information

• Chemical Name: 4-CHLORO-3-IODOPHENOL
• CAS No.: 202982-72-7
• Molecular Formula: C6H4 Cl I O
• Molecular Weight: 254.455
• Hs Code.: 2908199090
• Mol file: 202982-72-7.mol

Synonyms:4-Chloro-3-iodophenol

Chemical Property of 4-CHLORO-3-IODOPHENOL

Chemical Property:

• Vapor Pressure: 0.000288mmHg at 25°C
• Melting Point: 75-77°C
• Refractive Index: 1.677
• Boiling Point: 312.4°Cat760mmHg
• Flash Point: 142.7°C
• PSA: 20.23000
• Density: 2.087g/cm³
• LogP: 2.65020
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-3-iodophenol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-3-IODOPHENOL

There total 4 articles about 4-CHLORO-3-IODOPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-chloro-2-iodo-4-methoxybenzene (2401-25-4) → 4-chloro-3-iodophenol (202982-72-7)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 24h;

Reference yield: 80.0%

3-Iodophenol (626-02-8) → 2-chloro-3-iodophenol (666727-31-7) + 2-chloro-5-iodophenol (289039-26-5) + 4-chloro-3-iodophenol (202982-72-7)

Guidance literature:

With N-chloro-succinimide; (R)-[1,1′-binaphthalene]-2,2′-diylbis-(diphenylphosphine sulfide); In chloroform-d1; at 20 ℃; for 1h; regioselective reaction;

DOI:10.1021/acs.orglett.6b02650

Reference yield: 66.0%

→ 4-chloro-3-iodophenol (202982-72-7)

Guidance literature:

upstream raw materials:

3-iodo-4-chloroaniline

1-chloro-2-iodo-4-methoxybenzene

3-Iodophenol

Downstream raw materials:

t-butyl (4-chloro-3-iodophenoxy)acetate

C₉H₅ClINOS

C₁₁H₇ClINO

4-(4-chloro-3-iodophenoxy)benzonitrile

Refernces

• 1、 -. "5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS". Page/Page column 28. . Retrieved 2009/12/28.