(3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylicacidmethylester

Base Information

• Chemical Name: (3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylicacidmethylester
• CAS No.: 214335-16-7
• Molecular Formula: C14H18 Cl N O2
• Molecular Weight: 267.755
• Mol file: 214335-16-7.mol

Synonyms:(3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylicacidmethylester

Chemical Property of (3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylicacidmethylester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.532
• Boiling Point: 343.503°C at 760 mmHg
• Flash Point: 161.545°C
• PSA: 29.54000
• Density: 1.157
• LogP: 2.48620

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylicacidmethylester

There total 5 articles about (3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylicacidmethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

→ (-)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate (214335-16-7,205805-13-6)

Guidance literature:

Reference yield: 31.3%

(±)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate (205805-13-6) → (-)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate (214335-16-7,205805-13-6)

Guidance literature:

With O,O'-dibenzoyl-L-tartaric acid; In methanol; at 60 - 65 ℃; for 0.5h;

DOI:10.1021/op060114g

Reference yield:

arecoline (63-75-2) → (-)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate (214335-16-7,205805-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / diethyl ether / 0.5 h / -10 °C

In diethyl ether;

DOI:10.1021/jm980028+

upstream raw materials:

(±)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3β-carboxylate

arecoline

(4-chlorphenyl)magnesium bromide

Downstream raw materials:

(-)-Methyl 1-Methyl-4β-phenylpiperidine-3β-carboxylate

(3S,4S)-4-(4-chlorophenyl)-3-(hydroxymethyl)-1-methylpiperidine

(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

(+)-4β-(4-Chlorophenyl)-3α-(hydroxymethyl)-1-methylpiperidine

Refernces

• 1、 -. "Monomeric and dimeric heterocycles, and therapeutic uses thereof". . . Retrieved 2008/06/13.
• 2、 Kozikowski, Alan P.,Araldi, Gian Luca,Boja, John,Meil, William M.,Johnson, Kenneth M.,Flippen-Anderson, Judith L.,George, Clifford,Saiah, Eddine. "Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton". . p. 1962 - 1969. Retrieved 2007/10/03.