BOC-GLU(OTBU)-OSU

Base Information

• Chemical Name: BOC-GLU(OTBU)-OSU
• CAS No.: 32886-55-8
• Molecular Formula: C18H28 N2 O8
• Molecular Weight: 400.429
• Mol file: 32886-55-8.mol

Synonyms:Pentanoicacid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-5-oxo-,1,1-dimethylethyl ester, (4S)- (9CI); Pentanoic acid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-5-oxo-,1,1-dimethylethyl ester, (S)-; Succinimide, N-[(N-carboxy-L-a-glutamyl)oxy]-, di-tert-butylester (8CI)

Chemical Property of BOC-GLU(OTBU)-OSU

Chemical Property:

• PSA: 128.31000
• LogP: 1.93760
• Storage Temp.: -15°C

Purity/Quality:

98.5% ^*data from raw suppliers

Boc-L-glutamic acid γ-tert-butyl ester alpha-N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-GLU(OTBU)-OSU

There total 3 articles about BOC-GLU(OTBU)-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Boc-Glu(OtBu)-OH (13726-84-6) → (S)-5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate (32886-55-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 24h; Inert atmosphere;

DOI:10.1039/c5cc04953a

Reference yield:

→ BocGlu(OSu)OtBu (32886-55-8)

Guidance literature:

Boc-Glu(O-t-Bu), N-Hydroxysuccinimid;

Reference yield:

→ (S)-5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate (32886-55-8)

Guidance literature:

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Boc-Glu(OtBu)-OH

Downstream raw materials:

N-Boc-(S)-glutamic acid (tert-butyl ester)-mexiletine

mexiletine-(S)-glutamic acid amide hydrochloride

C₃₈H₅₀ClN₅O₁₁S

(S)-Boc-Glu(Ot-Bu)-NHBn

Refernces

• 1、 Kasai, Shota,Konno, Sho,Ishikawa, Fumihiro,Kakeya, Hideaki. "Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling". supporting information. p. 15764 - 15767. Retrieved 2015/11/10.