Technology Process of 2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione
There total 7 articles about 2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(1,3-dioxoisoindolin-2-yl)-N-hydroxyacetimidoyl chloride;
With
triethylamine;
In
tetrahydrofuran;
for 0.333333h;
Cooling with ice;
Inert atmosphere;
C20H23F3N2;
In
tetrahydrofuran; dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 60 °C
2.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice; Inert atmosphere
2.2: 2 h / 20 °C
With
N-chloro-succinimide; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium diacetate; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / Inert atmosphere; Reflux
2.1: dichloromethane / 2 h / Molecular sieve; Reflux
3.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice; Inert atmosphere
3.2: 2 h / 20 °C
With
palladium diacetate; sodium carbonate; triethylamine;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;