2-phenyl-3,4,5,6-tetramethylpyridine

Base Information

• Chemical Name: 2-phenyl-3,4,5,6-tetramethylpyridine
• CAS No.: 80206-51-5
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.307
• Mol file: 80206-51-5.mol

Synonyms:2-phenyl-3,4,5,6-tetramethylpyridine

Chemical Property of 2-phenyl-3,4,5,6-tetramethylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-3,4,5,6-tetramethylpyridine

There total 6 articles about 2-phenyl-3,4,5,6-tetramethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethylacetylene (503-17-3) + benzonitrile (100-47-0) → 2-phenyl-3,4,5,6-tetramethylpyridine (80206-51-5)

Guidance literature:

(η3-allyl)(η5-pentamethylcyclopentadienyl)cobalt; In hexane; at 20 ℃; for 72h;

Reference yield: 65.0%

1-Phenylprop-1-yne (673-32-5) + (2E,3E)-N-benzyl-3-methylpent-3-en-2-imine → 2,4,5,6-tetramethyl-3-phenylpyridine (1016970-76-5) + 2-phenyl-3,4,5,6-tetramethylpyridine (80206-51-5)

Guidance literature:

1-Phenylprop-1-yne; (2E,3E)-N-benzyl-3-methylpent-3-en-2-imine; In toluene; at 100 ℃; for 2h;

With air; palladium on activated charcoal; In 2,2,2-trifluoroethanol; toluene; at 75 ℃; for 12h;

With hydrogen; palladium on activated charcoal; In 2,2,2-trifluoroethanol; toluene; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/ja7104784

Reference yield:

C18H27NS2 → 2-phenyl-3,4,5,6-tetramethylpyridine (80206-51-5)

Guidance literature:

With hydrogenchloride; boron trifluoride diethyl etherate; mercury(II) oxide; In tetrahydrofuran; water; at 100 ℃; regiospecific reaction; Inert atmosphere;

DOI:10.1021/ja2105703

upstream raw materials:

dimethylacetylene

benzonitrile

1-Phenylprop-1-yne

(E)-3-methyl-2-(2-methyl-1,3-dithian-2-yl)pent-3-en-2-ol

Refernces

• 1、 Colby, Denise A.,Bergman, Robert G.,Ellman, Jonathan A.. "Synthesis of dihydropyridines and pyridines from imines and alkynes via C-H activation". . p. 3645 - 3651. Retrieved 2008/10/09.
• 2、 Hogeveen, H.,Kingma, R. F.,Kok, D. M.. "(Co)cyclodimerization of Alkynes by Aluminum Halides. Synthesis of Pyridines from Aluminum Halide ? Complexes of Cyclobutadienes and Nitriles". . p. 989 - 997. Retrieved 2007/10/02.