2,6-Dichlorophenylacetic acid chloride

Base Information

• Chemical Name: 2,6-Dichlorophenylacetic acid chloride
• CAS No.: 61875-53-4
• Molecular Formula: C₈H₅Cl₃O
• Molecular Weight: 223.486
• Mol file: 61875-53-4.mol

Synonyms:2,6-dichlorophenylacetylchloride

Chemical Property of 2,6-Dichlorophenylacetic acid chloride

Chemical Property:

Purity/Quality:

99%min. ^*data from raw suppliers

2-(2,6-dichlorophenyl)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dichlorophenylacetic acid chloride

There total 5 articles about 2,6-Dichlorophenylacetic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2,6-dichlorophenyl)acetic acid (6575-24-2) → 2,6-dichlorophenylacetylchloride (61875-53-4)

Guidance literature:

With thionyl chloride; In toluene; at 20 ℃; for 12h;

DOI:10.1021/op1002984

Reference yield:

2,6-dichlorophenylacetonitrile (3215-64-3) → 2,6-dichlorophenylacetylchloride (61875-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: SOCl₂

With thionyl chloride; sulfuric acid;

Reference yield:

1,3-Dichloro-2-chloromethyl-benzene (2014-83-7) → 2,6-dichlorophenylacetylchloride (61875-53-4)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂SO₄

3: SOCl₂

With thionyl chloride; sulfuric acid;

upstream raw materials:

2-(2,6-dichlorophenyl)acetic acid

2,6-dichlorophenylacetonitrile

1,3-Dichloro-2-chloromethyl-benzene

Downstream raw materials:

(2,6-Dichloro-phenyl)-ethaneperoxoic acid tert-butyl ester

ethyl 4-(2,6-dichlorophenyl)-3-oxobutanoate

2-(2,6-dichlorophenyl)-N,N-diethylacetamide

N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)-2-(2,6-dichlorobenzyl)oxazolo[5,4-d]pyrimidin-7-amine

Refernces

• 1、 Bruno, Ferdinando,Errico, Suann,Pace, Simona,Nawrozkij, Maxim B.,Mkrtchyan, Arthur S.,Guida, Francesca,Maisto, Rosa,Olga?, Abdurrahman,D'Amico, Michele,Maione, Sabatino,De Rosa, Mario,Banoglu, Erden,Werz, Oliver,Fiorentino, Antonio,Filosa, Rosanna. "Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation". . p. 946 - 960. Retrieved 2018/07/24.
• 2、 Forlani, Giuseppe,Berlicki, Lukasz,Duo, Mattia,Dziedziola, Gabriela,Giberti, Samuele,Bertazzini, Michele,Kafarski, Pawel. "Synthesis and evaluation of effective inhibitors of plant δ1-pyrroline-5-carboxylate reductase". . p. 6792 - 6798. Retrieved 2013/08/23.