1-Bromo-4-(4-chlorophenoxy)benzene

Base Information

• Chemical Name: 1-Bromo-4-(4-chlorophenoxy)benzene
• CAS No.: 30427-95-3
• Molecular Formula: C12H8 Br Cl O
• Molecular Weight: 283.552
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID10598281
• Nikkaji Number: J3.286.168G
• Wikidata: Q82494021
• Mol file: 30427-95-3.mol

Synonyms:1-BROMO-4-(4-CHLOROPHENOXY)BENZENE;30427-95-3;Benzene, 1-bromo-4-(4-chlorophenoxy)-;SCHEMBL6614179;DTXSID10598281;LYCPQRWCXNZZKX-UHFFFAOYSA-N;1-Bromo-4-(4-chlorophenoxyl)benzene;AKOS028109932;BS-22265;DS-021573;1-(4-BROMOPHENOXY)-4-CHLOROBENZENE;CS-0210788

Chemical Property of 1-Bromo-4-(4-chlorophenoxy)benzene

Chemical Property:

• Vapor Pressure: 0.000335mmHg at 25°C
• Melting Point: 42-43 °C
• Refractive Index: 1.61
• Boiling Point: 329.7°C at 760 mmHg
• Flash Point: 153.2°C
• PSA: 9.23000
• Density: 1.506g/cm³
• LogP: 4.89480
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 281.94471
• Heavy Atom Count: 15
• Complexity: 184

Purity/Quality:

97% ^*data from raw suppliers

1-BROMO-4-(4-CHLOROPHENOXY)BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1OC2=CC=C(C=C2)Br)Cl

Technology Process of 1-Bromo-4-(4-chlorophenoxy)benzene

There total 12 articles about 1-Bromo-4-(4-chlorophenoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-chloro-phenol (106-48-9,82344-39-6) + 5-(p-bromophenyl)thianthrenium bromide → 1-bromo-4-(4-chlorophenoxy)benzene (30427-95-3) + Thianthrene (92-85-3) + C24H16BrClOS2 + C30H20Cl2O2S2

Guidance literature:

4-chloro-phenol; With sodium; In diethyl ether;

5-(p-bromophenyl)thianthrenium bromide; In acetonitrile; at 80 ℃; for 48h;

DOI:10.1002/poc.585

Reference yield: 20.0%

→ 1-bromo-4-(4-chlorophenoxy)benzene (30427-95-3)

Guidance literature:

With pyridine; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere; Molecular sieve;

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) + 1-Bromo-4-fluorobenzene (460-00-4) → 1-bromo-4-(4-chlorophenoxy)benzene (30427-95-3)

Guidance literature:

With potassium hydroxide; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 72h; Large scale;

upstream raw materials:

4-Bromodiphenyl ether

4-chlorodiphenyl ether

4-amino-4'-chlorodiphenyl ether

4-(4-bromophenoxy)aniline

Downstream raw materials:

(4-bromo-phenyl)-(3,4-dichloro-phenyl)-ether

4-amino-4'-chlorodiphenyl ether

4-(p-Chlorphenoxy)-benzolphosphonsaeure

2-chloro-1-[4-(4-chlorophenoxy)phenyl]ethanone

Refernces

• 1、 Wang, Ying,Li, Lina,Ji, Hongwei,Ma, Wanhong,Chen, Chuncheng,Zhao, Jincai. "Iron(III)-mediated photocatalytic selective substitution of aryl bromine by chlorine with high chloride utilization efficiency". supporting information. p. 2344 - 2346. Retrieved 2014/03/21.
• 2、 Qian, Ding-Quan,Shine, Henry J.,Thurston, John H.,Whitmire, Kenton H.. "Nucleophilic reactions of 5-(aryl)thianthrenium bromides with sodium aryl oxides". . p. 142 - 147. Retrieved 2007/10/03.