Multi-step reaction with 6 steps
1.1: zinc; water / N,N,N,N,N,N-hexamethylphosphoric triamide / 3.75 h / 18 - 28 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22.3 h / 0 - 20 °C
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 17 h / 20 - 86.6 °C
3.2: 20 °C
4.1: triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 2.17 h / -50 - 0 °C
5.1: methoxybenzene; trifluorormethanesulfonic acid / dichloromethane / 0.58 h / -30 - -2 °C
5.2: 0.5 h / -10 - 3 °C
6.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave
With
trifluorormethanesulfonic acid; water; potassium carbonate; caesium carbonate; methoxybenzene; triethylamine tris(hydrogen fluoride); 3-chloro-benzenecarboperoxoic acid; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate; potassium iodide; zinc;
palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;