C₄₄H₄₀N₆O₃

Base Information

• Chemical Name: C₄₄H₄₀N₆O₃
• CAS No.: 1361024-33-0
• Molecular Formula: C₄₄H₄₀N₆O₃
• Molecular Weight: 700.84
• Mol file: 1361024-33-0.mol

Synonyms:C₄₄H₄₀N₆O₃

Chemical Property of C₄₄H₄₀N₆O₃

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Butyl-1,6-dihydro-4-methyl-6-oxo-1-[[2''-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1''-biphenyl]-4-yl]methyl]-5-pyrimidineaceticAcid(FimasartanImpurity) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Butyl-1,6-dihydro-4-methyl-6-oxo-1-[[2''-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1''-biphenyl]-4-yl]methyl]-5-pyrimidineacetic Acid (Fimasartan Impurity) is a Fimasartan impurity, and also functions as a reagent in the synthesis and in the antihypertensive activity of pyrimidin-4(3H)-one derivative as losartan analogue

Technology Process of C₄₄H₄₀N₆O₃

There total 3 articles about C₄₄H₄₀N₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C46H44N6O3 (503155-66-6) → C44H40N6O3 (1361024-33-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2011.12.116

Reference yield:

C13H20N2O3 (503155-65-5) → C44H40N6O3 (1361024-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydride / ethyl acetate; N,N-dimethyl-formamide

2: water; sodium hydroxide / methanol / 20 °C

With water; lithium hydride; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.12.116

Reference yield:

pentanonitrile (110-59-8) → C44H40N6O3 (1361024-33-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / methanol / 0 °C

2: sodium ethanolate / ethanol

3: lithium hydride / ethyl acetate; N,N-dimethyl-formamide

4: water; sodium hydroxide / methanol / 20 °C

With hydrogenchloride; water; sodium ethanolate; lithium hydride; sodium hydroxide; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.12.116

upstream raw materials:

C₁₃H₂₀N₂O₃

C₄₆H₄₄N₆O₃

pentanonitrile

Downstream raw materials:

C₄₈H₄₇N₇O₂

C₄₉H₄₉N₇O₂

C₄₈H₄₇N₇O₃

C₄₈H₄₇N₇O₂S

Refernces