Technology Process of 4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide
There total 5 articles about 4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diphenylphosphoranyl azide; triethylamine;
In
dimethyl sulfoxide;
at 20 ℃;
for 48h;
DOI:10.1021/jo010283t
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / TRIS buffer; conc. HCl; ZnCl2 / carboxypeptidase G / H2O / 48 h / 38 °C / pH 7.2
2: 83 percent / diphenylphosphoryl azide; Et3N / dimethylsulfoxide / 20 h
With
hydrogenchloride; Tris buffer; diphenylphosphoranyl azide; triethylamine; zinc(II) chloride;
carboxypeptidase G;
In
water; dimethyl sulfoxide;
1: Hydrolysis / 2: Substitution;
DOI:10.1021/ja971568j
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Ph3P; Br2 / various solvent(s) / 20 °C
1.2: 70 percent / N,N-diisopropylethylamine / various solvent(s) / 30 h / 45 °C
2.1: 85 percent / diphenylphosphoryl azide; triethylamine / dimethylsulfoxide / 48 h / 20 °C
With
diphenylphosphoranyl azide; bromine; triethylamine; triphenylphosphine;
In
dimethyl sulfoxide;
DOI:10.1021/jo010283t