L-NIL dihydrochloride

Base Information

• Chemical Name: L-NIL dihydrochloride
• CAS No.: 159190-45-1
• Molecular Formula: C8H19Cl2N3O2
• Molecular Weight: 260.16
• European Community (EC) Number: 803-059-8
• Mol file: 159190-45-1.mol

Synonyms:L-NIL dihydrochloride;159190-45-1;epsilon-Acetimidoyllysine dihydrochloride;L-NILdihydrochloride;SCHEMBL7974005;AKOS025294631;AS-82086;2-amino-6-(1-aminoethylideneamino)hexanoic acid;dihydrochloride

Chemical Property of L-NIL dihydrochloride

Chemical Property:

• Boiling Point: 369 °C at 760 mmHg
• Flash Point: 177 °C
• PSA: 99.20000
• LogP: 2.95030
• Storage Temp.: -20°C
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 259.0854322
• Heavy Atom Count: 15
• Complexity: 192

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-N6-(1-Iminoethyl)lysine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NCCCCC(C(=O)O)N)N.Cl.Cl
• Description: L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
• Uses: L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor: to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murineto study its effects on leptin-induced inflammation in hepatocytes to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)