H-L-CYS(TRT)-NH2 HCL

Base Information

• Chemical Name: H-L-CYS(TRT)-NH2 HCL
• CAS No.: 166737-85-5
• Molecular Formula: C22H22N2OS
• Molecular Weight: 362.495
• Mol file: 166737-85-5.mol

Synonyms:Propanamide,2-amino-3-[(triphenylmethyl)thio]-, (R)-;S-Trityl-L-cysteine amide;

Chemical Property of H-L-CYS(TRT)-NH2 HCL

Chemical Property:

• Appearance/Colour: a white crystalline powder
• Vapor Pressure: 2.19E-11mmHg at 25°C
• Refractive Index: 1.626
• Boiling Point: 531.681 °C at 760 mmHg
• PKA: 15.83±0.50(Predicted)
• Flash Point: 275.351 °C
• PSA: 94.41000
• Density: 1.183 g/cm³
• LogP: 5.72690
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

(2R)-2-Amino-3-[(triphenylmethyl)thio]propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2R)-2-Amino-3-[(triphenylmethyl)thio]propanamide is a useful building block for organic synthesis.

Technology Process of H-L-CYS(TRT)-NH2 HCL

There total 4 articles about H-L-CYS(TRT)-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(R)-(9H-fluoren-9-yl)methyl (1-amino-1-oxo-3-(triphenylmethylthio)propan-2-yl)carbamate (202752-01-0) → (2R)-2-Amino-3-(tritylsulfanyl)propanamide (166737-85-5)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield: 57.0%

S-trityl-L-cysteine methyl ether (58885-35-1,115545-85-2) → (2R)-2-Amino-3-(tritylsulfanyl)propanamide (166737-85-5)

Guidance literature:

With ammonia; In methanol; at -78 - 20 ℃; for 14h;

Reference yield:

C(Trt) (97802-29-4) → (2R)-2-Amino-3-(tritylsulfanyl)propanamide (166737-85-5)

Guidance literature:

With thionyl chloride; In methanol;

upstream raw materials:

S-trityl-L-cysteine methyl ether

C(Trt)

(R)-(9H-fluoren-9-yl)methyl (1-amino-1-oxo-3-(triphenylmethylthio)propan-2-yl)carbamate

N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine

Downstream raw materials:

N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucyl-S-trityl-L-cysteinamide

Refernces

• 1、 Bogart, Jonathan W.,Bowers, Albert A.. "Thiopeptide Pyridine Synthase TbtD Catalyzes an Intermolecular Formal Aza-Diels-Alder Reaction". supporting information. p. 1842 - 1846. Retrieved 2019/01/30.
• 2、 -. "CATHEPSIN CYSTEINE PROTEASE INHIBITORS". Page/Page column 43-44. . Retrieved 2008/12/04.