3-(4-METHOXYPHENYL)PYRAZOLE

Base Information

• Chemical Name: 3-(4-METHOXYPHENYL)PYRAZOLE
• CAS No.: 27069-17-6
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Hs Code.: 29331990
• Mol file: 27069-17-6.mol

Synonyms:3-(4-Methoxyphenyl)-1H-pyrazole;3-(4-Methoxyphenyl)Pyrazole;5-(4-Methoxyphenyl)-1H-pyrazole;Pyrazole, 5-(4-methoxyphenyl)-;4-ethoxy-1-pyrazol-3-ylbenzene;

Chemical Property of 3-(4-METHOXYPHENYL)PYRAZOLE

Chemical Property:

• Appearance/Colour: White to light yellow crystalline powder
• Vapor Pressure: 1.97E-05mmHg at 25°C
• Melting Point: 127-130 °C
• Refractive Index: 1.58
• Boiling Point: 373.1 °C at 760 mmHg
• PKA: 13.60±0.10(Predicted)
• Flash Point: 135.9 °C
• PSA: 37.91000
• Density: 1.159 g/cm³
• LogP: 2.08530
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Methoxyphenyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-METHOXYPHENYL)PYRAZOLE

There total 23 articles about 3-(4-METHOXYPHENYL)PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(E)-3-butoxy-1-(4-methoxyphenyl)prop-2-en-1-one (115270-35-4) → 3-p-methoxyphenylpyrazole (27069-17-6)

Guidance literature:

With hydrazine solvate; In acetid acid; at 85 ℃; for 16h;

DOI:10.1021/ol300837d

Reference yield: 90.0%

3-dimethylamino-4'-methoxyacrylophenone (18096-70-3,78090-00-3) → 3-p-methoxyphenylpyrazole (27069-17-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1155/2019/2467970

Reference yield: 83.0%

N'-(4-methoxybenzylidene)-4-methylbenzenesulfonohydrazide (19350-72-2) + calcium carbide (75-20-7) → 3-p-methoxyphenylpyrazole (27069-17-6)

Guidance literature:

With water; caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 6h; Schlenk technique;

DOI:10.1039/c6gc02776h

upstream raw materials:

2-Dimethylamino-4,4-diethoxy-2-(4-methoxy-phenyl)-butyronitrile

para-iodoanisole

N-tosyl-N-propargylhydrazine

3-(4-methoxy-phenyl)-3-oxo-propionaldehyde

Downstream raw materials:

{(η6-p-cymene)RuCl2(3-(4'-methoxyphenyl)pyrazole)}

Refernces

• 1、 Stephan, Marvin,Panther, Jesco,Wilbert, Fabio,Ozog, Pauline,Müller, Thomas J. J.. "Heck Reactions of Acrolein or Enones and Aryl Bromides – Synthesis of 3-Aryl Propenals or Propenones and Consecutive Application in Multicomponent Pyrazole Syntheses". supporting information. p. 2086 - 2092. Retrieved 2020/03/23.
• 2、 Bhat, Mashooq Ahmad,Al-Omar, Mohamed A.,Naglah, Ahmed M.,Khan, Abdul Arif,Bonomo, Maria Grazia. "Enaminone-Derived Pyrazoles with Antimicrobial Activity". . . Retrieved 2019/11/25.