D-ASPARTIC ACID-BETA-METHYL ESTER

Base Information

• Chemical Name: D-ASPARTIC ACID-BETA-METHYL ESTER
• CAS No.: 21394-81-0
• Molecular Formula: C5H9NO4
• Molecular Weight: 147.13
• Hs Code.: 2922509090
• Mol file: 21394-81-0.mol

Synonyms:Asparticacid, 4-methyl ester, D- (7CI,8CI);D-Aspartic acid b-methyl ester;

Chemical Property of D-ASPARTIC ACID-BETA-METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000242mmHg at 25°C
• Melting Point: 188-190 °C
• Refractive Index: 1.477
• Boiling Point: 301.7 °C at 760 mmHg
• PKA: 2.16±0.23(Predicted)
• Flash Point: 136.3 °C
• PSA: 89.62000
• Density: 1.299 g/cm³
• LogP: 0.46370
• Storage Temp.: Store at 0-5°C

Purity/Quality:

99% ^*data from raw suppliers

H-D-ASP(OME)-OHHCL 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-ASPARTIC ACID-BETA-METHYL ESTER

There total 4 articles about D-ASPARTIC ACID-BETA-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

dimethyl D-aspartate (6384-18-5,40149-67-5,88067-96-3) → (R)-2-amino-4-methoxy-4-oxobutanoic acid (21394-81-0)

Guidance literature:

With potassium phosphate buffer; for 5h; Ambient temperature; porcine liver esterase;

DOI:10.1021/jo00129a066

Reference yield: 90.0%

methanol (67-56-1) + (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → (R)-2-amino-4-methoxy-4-oxobutanoic acid (21394-81-0)

Guidance literature:

With acetyl chloride; at 0 - 25 ℃;

Reference yield:

β-methyl L-aspartate (2177-62-0) → (R)-2-amino-4-methoxy-4-oxobutanoic acid (21394-81-0)

Guidance literature:

In water; at 140 ℃; Rate constant; pH 8.0;

DOI:10.1021/jo00280a017

upstream raw materials:

methanol

(2R)-aspartic acid

β-methyl L-aspartate

dimethyl D-aspartate

Downstream raw materials:

(2R)-2-[(tert-butoxycarbonyl)amino]-4-methoxy-4-oxobutanoic acid

(R)-1-benzyl 4-methyl 2-(tert-butoxycarbonylamino)succinate

(R)-4-Isobutoxycarbonyloxy-4-oxo-3-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid methyl ester

β-Methyl (2R)-N-(9'-phenylfluoren-9'-yl)aspartate ester

Refernces

• 1、 -. "Novel method for synthesizing methyl aspartate". Paragraph 0021-0022. . Retrieved 2017/06/20.
• 2、 Smith, Grant Gill,Reddy, G. Vanita. "Effect of the Side Chain on the Racemization of Amino Acids in Aqueous Solution". . p. 4529 - 4535. Retrieved 2007/10/02.