L-Histidine, N-glycyl-

Base Information

• Chemical Name: L-Histidine, N-glycyl-
• CAS No.: 2489-13-6
• Molecular Formula: C8H12 N4 O3
• Molecular Weight: 212.208
• Hs Code.: 2933290090
• DSSTox Substance ID: DTXSID60947785
• Mol file: 2489-13-6.mol

Synonyms:L-Histidine, N-glycyl-;(2S)-2-[(2-aminoacetyl)amino]-3-(4H-imidazol-4-yl)propanoic acid;SCHEMBL2779466;DTXSID60947785;N-(2-Amino-1-hydroxyethylidene)-3-(4H-imidazol-4-yl)alanine

Chemical Property of L-Histidine, N-glycyl-

Chemical Property:

• Vapor Pressure: 3.33E-18mmHg at 25°C
• Melting Point: 178℃
• Refractive Index: 1.604
• Boiling Point: °Cat760mmHg
• PKA: 2.86±0.10(Predicted)
• Flash Point: °C
• PSA: 121.10000
• Density: 1.56g/cm³
• LogP: -0.42850
• Storage Temp.: −20°C
• XLogP3: -4.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 212.09094026
• Heavy Atom Count: 15
• Complexity: 313

Purity/Quality:

99%+, ^*data from raw suppliers

H-Gly-His-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC=NC1CC(C(=O)O)NC(=O)CN
• Isomeric SMILES: C1=NC=NC1C[C@@H](C(=O)O)NC(=O)CN

Technology Process of L-Histidine, N-glycyl-

There total 10 articles about L-Histidine, N-glycyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-Z-glycylhistidine benzyl ester (31321-63-8) → GH (2489-13-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; acetic acid; Ambient temperature;

Reference yield:

glycyl-glycyl-L-histidine (7451-76-5) → GH (2489-13-6) + glycine (56-40-6,18875-39-3,25718-94-9)

Guidance literature:

With (Et₂NH₂)₈[{α-PW₁₁O₃₉Zr-(μ-OH)(H₂O)}₂]*7H₂O; water; 3-(trimethylsilyl)propionic-2,2,3,3-d₄ acid sodium salt; In water-d2; at 60 ℃; Reagent/catalyst;

DOI:10.1002/ejic.201500161

Reference yield:

Nα-(N,N-phthaloyl-glycyl)-L-histidine (503622-97-7) → GH (2489-13-6)

Guidance literature:

With ethanol; water; hydrazine hydrate;

DOI:10.1021/ja01106a032

upstream raw materials:

N^α-(N,N-phthaloyl-glycyl)-L-histidine

N-Z-glycylhistidine benzyl ester

benzyl (2-azido-2-oxoethyl)carbamate

L-Histidine methyl ester

Downstream raw materials:

C₂₄H₂₈N₈O₈S₂

glycine

L-histidine

Refernces

• 1、 Stadlbauer, Stefan,Riechers, Alexander,Spaeth, Andreas,Koenig, Burkhard. "Utilizing reversible copper(II) peptide coordination in a sequence-selective luminescent receptor". supporting information; experimental part. p. 2536 - 2541. Retrieved 2009/04/11.
• 2、 Yokoyama,Aiba,Tanaka. "Acid dissociation constants of some histidine containing peptides and formation constants of their metal complexes". . p. 112 - 117. Retrieved 2007/10/04.